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| Correlation between expression of survivin and neoadjuvant chemotherapy in gastric cancer tissue |
| 1 LIU Jing-wen, 2 WANG Qian |
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Abstract Objective To observe the expression of survivin in advanced gastric cancer before and after neoadjuvant chemotherapy based on S-1 (tegafur gimeracil oteracil potassium capsule), and to explore the relationship between the expression of survivin in advanced gastric cancer and neoadjuvant chemotherapy in gastric cancer. Methods 60 patients with advanced gastric cancer who received neoadjuvant chemotherapy based on S-1 and gastric cancer surgery were enrolled in the study. According to the pathological changes of gastric cancer patients, the curative effect of the patients after neoadjuvant chemotherapy was determined, and the patients were classified as chemo-effective and chemo-noneffective groups. Through dectecting the expression level of survivin in pathological examination of endoscopic diagnostic specimens before chemotherapy and surgical excision tissue with neoadjuvant chemotherapy, then the relationship between survivin expression in gastric cancer before and after neoadjuvant chemotherapy based on S-1 was analyzed. Results There was significant difference in the expression of survivin before neoadjuvant chemotherapy between the chemo-effective and the chemo-noneffective groups (P<0.05). After neoadjuvant chemotherapy based on S-1, the expression of survivin significantly increased in the gastric cancer tissue (P<0.05). The variation of survivin expression after neoadjuvant chemotherapy based on S-1 was not correlated between the chemo-effective and the chemo-noneffective groups (P>0.05). Conclusions The low expression of survivin in patients with gastric cancer may be sensitive to neoadjuvant chemotherapy based on S-1, the effect of chemotherapy is good, the increased expression of survivin after neoadjuvant chemotherapy based on S-1 may be associated with chemoresistance of gastric cancer, which may reduce the effect of chemotherapy; detecting the expression of survivin can help to predict the sensitivity of neoadjuvant chemotherapy based on S-1 for gastric cancer.
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