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Abstract To observe the value of Glasgow prognostic score (GPS) based on systemic inflammatory response in evaluating nutritional status and performance status in patients with gastric cancer. Methods 43 patients with gastric cancer hospitalized in our hospital from January 2013 to March 2014 with body composition measurement and hematological data were collected. The relationship between GPS score and nutritional， performance status were analyzed. Results In 43 gastric cancer patients， there were 18 males and 25 females. There were 27， 14 and 2 patients with GPS scores of 0， 1 and 2， respectively. It was found there was no significant statistical relationship between GPS score with NRS 2002 (nutrition risk screening， NRS 2002) score and PG-SGA (patient-generated subjective global assessment) score. The serum level of prealbumin in patients with GPS score ≥1 was significantly lower than that of patients with GPS score 0 (P=0.048)， and there was a trend to decline in blood lymphocyte count (P=0.078). The KPS score of patients with GPS score ≥ 1 was lower (P=0.015)， and there was a trend of correlation between GPS and quality of life (P=0.076). In analysis involving body composition measurement， the mid-upper arm circumference in patients with GPS score ≥1 turned to be significantly smaller than that of GPS score 0 (P=0.042). The maximum circumferences of both legs were also obviously smaller in patients with GPS ≥1 than that of GPS 0. The upper arm muscle circumference， triceps skin fold thickness and non-dominant hand grip strength were all reduced， but no significant statistical difference was found between patients with GPS ≥1 and GPS 0. Conclusion GPS score is based on systemic inflammatory response and related to parts of nutritional indicators and performance status of gastric cancer patients. It is a promising simplified alternative index for nutritional and performance status assessment of gastric cancer patients.
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