Abstract Objective To observe the efficacy and toxicities of thalidomide plus icotinib in the treatment of advanced pulmonary adenocarcinoma. Methods Totally 63 patients with pulmonary adenocarcinoma in the third affiliated hospital of Anhui medical college were selected for study from January 2013 to June 2015. The patients were randomly divided into control and experimental groups， control group of 30 patients received icotinib； the experimental groups， 33 cases received thalidomide combined with icotinib. The clinical efficacy， adverse reactions， survival rate and the changes of the serum vascular endothelial growth factor (VEGF)， interleukin-8(IL-8) tumor necrosis factor α (TNF-α)； fibroblast growth factor (bFGF) of the two groups were observed and compared. Results No significant differences were found in adverse reactions， such as rash， diarrhea， abnormal liver and renal function and occurrence of bone narrow suppression of both groups. The incidence of occult blood of stool in experimental groups were higher than the control groups. The objective response rate (ORR) of the control group was 43.33%， while that of the experimental group was 69.70% (P<0.05). The PFS of the experimental group was 21.12±6.56 months， while that of the control group was 19.77±6.61 months (P=0.073). The VEGF levels in the control groups were significantly lower than the experimental groups 295.0 (122.67~572.54)vs 148.0 (56.33~337.42) pg/ml(P<0.01). IL-8， TNF-α and bFGF levels between the two groups (P=0.0585)， there was no statistical difference. But IL-8 and TNF-α levels in the experimental group were lower than the control group， and bFGF levels in the experimental group were higher than the control group， suggesting a trend of difference between the two groups. Conclusion Thalidomide combining with icotinib hydrochloride is effective and well tolerated in patients with advanced pulmonary adenocarcinoma. It may be a rational choice for the standard and individualized treatment of advanced pulmonary adenocarcinoma.
JIANG Qian,WANG Yi,SUN Xiang. Clinical study of thalidomide plus Icotinib hydrochloride in the treatment of advanced pulmonary adenocarcinoma[J]. Electron J Metab Nutr Cancer, 2019, 6(2): 216-220.
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[1]
1XYi-jie, 1WANG Zhi-chao, HOU Gao-fen1FAN Yue-ping, 1ZHOU Ai-mei, 2ZHAO Wen-zhi, 2YU Kai-ying,2AO Ben-qiang,2SHI Han-ping. Safety of high-dose vitamin C in cancer patients[J]. Electron J Metab Nutr Cancer, 2018, 5(4): 399-402.
