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Abstract Objective Apatinib is currently the first effective oral anti-tumor angiogenesis drug for the treatment of patients with advanced chemotherapy-resistant gastric cancer. This study is to explore the effects of immune enteral nutrition treatment on the nutritional status and toxicity of advanced gastric cancer patients undergoing apatinib. Methods From January 2016 to September 2018，108 patients with gastric cancer selected from Aviation Gerneral Hospital were randomly divided into the treatment group and the control group. The observation group (n = 54) was treated with immune enteral nutritional support and apatinib， the control group (n = 54) was given normal diet direction and apatinib. Before and after 2 cycles， two groups were assessed and evaluated in terms of the nutritional status， toxicity reaction and nosocomial infection rate. Results Before treatment， the clinical data such as mean age， gender， types of cancer and nutritional index between the two groups were all no statistical significance (P>0.05). After treatment， the body mass index， albumin level and prealbumin level of observation group were all significantly better than those of the control group. The incidence of nosocomial infection in the observation group was significantly lower than in the control group (P<0.05). After two cycles of treatment， the body mass index， albumin level and prealbumin level of observation group were all higher than before (P<0.05). In contrast， the body mass index， hemoglobin， albumin and prealbumin level of control group were all lower than before (P<0.05).Regarding the adverse reactions of apatinib， the incidences of fatigue， myelosuppression and diarrhea were all significantly different(P<0.05). However， there was no statistical difference of efficiency between the two groups. Conclusions Providing enteral nutritional therapy to advanced gastric cancer patients undergoing antiangiogenic treatment can not only improve the nutrition status， but also alleviate the antiangiogenic-induced adverse reaction and the incidence of nosocomial infection.
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