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| Value of controlling nutritional status score for evaluating prognosis of patients with epithelial ovarian cancer |
| Wang Xueyin,Wang Jin |
| Department of Obstetrics and Gynecology Jiangning Hospital Affiliated to Nanjing Medical University Nanjing 211100 Jiangsu China |
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Abstract Objective To evaluate the prognostic value of controlling nutritional status CONUT score in patients with epithelial
ovarian cancer. Method A total of 158 patients with epithelial ovarian cancer into Jiangning Hospital Affiliated to Nanjing Medical
University from January 2017 to June 2020 were retrospectively summarized. The optimal cut - off value of CONUT score before
treatment for predicting overall survival OS rate was obtained by receiver operator characteristic ROC curve and the relationship
between clinicopathological factors and CONUT score was analyzed. Univariate and multivariate Cox proportional hazard models were
used to screen risk factors and Kaplan-Meier analysis was used to analyze the correlation between CONUT score and OS rate. Result
The median follow-up time was 35. 0 months the CONUT score was 0-12 points the area under the curve AUC was 0. 775 and
the cut-off value was 2. 7. The patients were divided into high-score group ≥ 3 points 71 cases and low-score group < 3 87
cases. The age of patients≥ 58 years old in high-score group FIGO stage Ⅲ-Ⅳ moderate to large amount of ascites neoadjuvant
chemotherapy + interval debulking surgery and chemotherapy resistance were significantly higher than those in low-score group P <
0. 05 . Univariate and multivariate Cox analysis showed that CONUT score ≥ 3 points was the independent risk factor to OS P <
0. 05 . The OS rate of high-score group was significantly lower than that of low-score group P< 0. 05 . Conclusion CONUT score of
patients with epithelial ovarian cancer is related to patients ' age FIGO stage ascites clinical treatment and chemotherapy
resistance. CONUT score ≥ 3 has a good application value in evaluating poor prognosis.
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Received: 11 January 2023
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