|
|
|
| Longitudinal investigation on nutritional risk and nutritional status of children with malignant tumor during treatment |
| 1Zhao Wenli,1Yan Jie,2Su Yan,1Wang Meichen,1Yang Wenli,2Duan Yanlong |
| 1Department of Clinical Nutrition Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing
100045 China
2Medical Oncology Department Pediatric Oncology Center Beijing Children's Hospital Capital Medical University
National Center for Children's Health Beijing Key Laboratory of Pediatric Hematology Oncology Key Laboratory of Major Diseases in
Children Ministry of Education Beijing 100045 China. |
|
|
|
|
Abstract Objective To investigate and evaluate the malnutrition risk and nutritional status of children with cancer from diagnosis
to treatment for 6 months To compare the nutritional status of children with lymphoma and solid tumor. Method The nutritional status
of 76 children with primary malignant tumors treated in the Department of oncology of Beijing Children's Hospital from July 2019 to
November 2021 was analyzed retrospectively. Weight height and upper arm circumference MUAC before initial treatment 1 month 3
months and 6 months after chemotherapy were measured. Nutritional risk screening and nutritional status assessment were conducted at
these four time points. The 24-hour dietary intake and blood examination were investigated at the four time points. The complications
one month after chemotherapy and nutritional support during 6 months of treatment were collected through medical records. The
nutritional status of children with lymphoma and solid tumor were compared. Result The incidence of malnutrition in 76 children before
chemotherapy was 15. 8% 12 / 76 32. 9% 25 / 76 at 1 month 25. 0% 19 / 76 at 3 months and 26. 3% 20 / 76 at 6
months after chemotherapy. There were significant differences among the four time points P < 0. 001 . The overweight / obesity rate
was 13. 2% 10 / 76 before chemotherapy 7. 9% 6 / 76 at 1 month 5. 3% 4 / 76 at 3 months and 6. 6% 5 / 76 at 6 months
after chemotherapy. The difference between the four time points was statistically significant P < 0. 001 There were significant
differences in malnutrition score BMI upper arm circumference scan score and total energy intake among the four time points P < 0. 001 . After 3 months of chemotherapy the nutritional status was the worst in 1 month. Comparison between the two groups Six
months after chemotherapy dystrophy score 0±0. 9 vs -0. 5±0. 9 BMI 15. 9±2. 1 kg / m
2
vs 14. 8±2. 2 kg / m
2
upper
arm circumference 17. 4±2. 0 cm vs 16. 2±2. 9 cm SCAN score 1 1 9 vs 2 1 9 hemoglobin 103. 0±15. 0 g / L vs
94. 2±13. 5 g / L number of malnutrition cases 7 16. 3% vs 13 39. 4% lymphoma group was superior to solid tumor group
the difference was statistically significant P< 0. 05 . Conclusion In view of the poor nutritional status of children receiving highintensity chemotherapy nutritional screening and evaluation should be strengthened to find children with nutritional risks as early as
possible and actively intervene to improve their tolerance to chemotherapy and quality of life.
|
|
Received: 30 November 2022
|
|
|
|
|
|
|
