早期肠内免疫营养对胃肠癌术后疗效及预后的研究

doi:10.16689/j.cnki.cn11-9349/r.2020.04.019

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Abstract Objective To investigate the effect of early enteral immunonutritional nutrition (EIN) support therapy on postoperative clinical efficacy and prognosis of patients with gastrointestinal cancer. Methods Eighty postoperative patients with gastrointestinal cancer admitted to our hospital from January 2015 to December 2018 were randomly divided into the experimental group and the control group according to the random number method, with 40 patients in each group receiving early enteral nutrition support treatment in the experimental group and total parenteral nutrition support treatment in the control group, to observe the clinical efficacy of the two groups of patients, including serum total protein (TP), serum prealbumin (PA), albumin (ALB), transferrin (TF) and other nutritional status, humoral immune indicators (IgM, IgA, IgG and IgG) cellular immune indicators (CD3+, CD4+, CD8+) and other immune functions, gastrointestinal function, the prognosis of postoperative gastrointestinal complications in the two groups was compared after 1 year of follow-up. Results After early postoperative enteral immunonutritional nutrition treatment, TP, PA, ALB, TF levels, IgM, IgA, IgG levels, CD3+, CD4+ levels in the Experimental group were significantly higher than those before treatment and the control group, and CD8+ levels were significantly lower than those before treatment and the control group, with statistically significant differences (P<0.05). Compared with the control group, the experimental group’s first exhaust time, first defecation time, first feeding time, bowel sound recovery time and hospitalization time were significantly shortened (P<0.05)；the incidence of postoperative gastrointestinal complications in the experimental group was significantly lower than that in the control group, with statistically significant difference (P<0.05). Conclusion The clinical effect of early enteral immunonutritional nutrition support treatment after gastrointestinal cancer is significant, which can improve the nutritional status and immune function, promote the recovery of gastrointestinal function, reduce the occurrence of gastrointestinal complications, and effectively improve the prognosis of patients.

Key words： Enteral immunonutritional nutrition support therapy Gastrointestinal cancer Clinical efficacy Prognosis research

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	Articles by authors
	Liu Xiaofei
	Luo Hongyu
	Li Guoquan
	Guo Chaohui
	Zhang Jingyi

Cite this article:

Liu Xiaofei,Luo Hongyu,Li Guoquan, et al. The efficacy and prognosis of early enteral immunonutrition in postoperative patients with gastrointestinal cancer[J]. Electron J Metab Nutr Cancer, 2020, 7(4): 474-478.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11-9349/r.2020.04.019 OR http://182.92.200.144/EN/Y2020/V7/I4/474

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