Effect of neoadjuvant chemotherapy combined with nutritional support in patients with primary lung cancer
Zhang Li1, Xue Jing2
1.Department of Physical Examination, Guangyuan Central Hospital, Guangyuan 628000, Sichuan, China；2.Department of Respiratory Medicine, the First Affiliated Hospital of Xian Jiaotong University, Xian 710000, Shaanxi, China
Abstract Objective To explore the effect of neoadjuvant chemotherapy (NAC) combined with nutritional support in patients with primary lung cancer, and to provide a reference for its clinical research. Methods Eighty-eight patients diagnosed with primary lung cancer were selected as the research subjects. All patients were treated with NAC. They were divided equally into observation group and control group by random number method. The control group was given conventional diet and the observation group was given nutrition support treatment. The differences in nutritional status (including total protein, albumin, and prealbumin), lung function, and T cell subsets were compared before NAC and after 4 courses of treatment. Results After NAC, the nutrition index level of the control group was lower than that before NAC, and the difference was statistically significant (P<0.05)；the nutrition index of the observation group after NAC was higher than that of the control group (P<0.05). After NAC, FEV1, MVV, V/Q, and RV/TCL in the control group were lower than before NAC (P<0.05)；V/Q and RV/TCL in the observation group after NAC were lower than before NAC (P<0.05)；The FEV1, MVV and V/Q of the group were higher than those of the control group (P<0.05)；the RV/TCL of the observation group after NAC was lower than that of the control group (P<0.05). CD4+/CD8+in the observation group after NAC was lower than before NAC (P<0.05)；CD4+, CD4+/CD8+in the control group after NAC were lower than before NAC (P<0.05)；CD4+, CD4+/CD8+in the observation group after NAC were higher than the control Group (P<0.05). Conclusion Nutritional support can significantly improve the nutritional decline caused by NAC treatment in patients with primary lung cancer, reduce lung function damage caused by chemotherapeutic drugs, and ensure that patients have better immune function, which is worthy of clinical application.
Zhang Li,Xue Jing. Effect of neoadjuvant chemotherapy combined with nutritional support in patients with primary lung cancer[J]. Electron J Metab Nutr Cancer, 2020, 7(4): 479-483.
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