血小板与淋巴细胞比值同小细胞肺癌临床预后的相关性分析

doi:10.16689/j.cnki.cn11-9349/r.2019.02.008

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Abstract Objective To investigate the relationship between platelet to lymphocyte ratio (PLR) and prognosis in patients with small cell lung cancer (SCLC). Methods Clinical data， including platelet and lymphocyte counts， of 165 patients with SCLC admitted to our hospital from June 2008 to June 2018 were collected and retrospectively analyzed and their survival were followed up. The optimal cut-off value of PLR was determined with time-dependent receiver operating curve (ROC curve) analysis in SPSS 22.0 statistical software. The overall survival (OS) and progression-free survival (PFS) of high PLR and low PLR groups were evaluated with Kaplan-Meier analysis respectively and Multivariate Cox regression models were applied to evaluate the independent prognostic significance of PLR. Results ROC curve analysis showed that PLR ＝ 189 was optimal cut-off value. One hundred and twenty cases were found in the low PLR (<189) group and 45 cases fell in the high PLR (≥189) group. The progression-free survival of patients with low PLR was higher than that of high PLR (8.6 months vs 6 months， P=0.016). The overall survival of patients with low PLR was higher than that of high PLR (13.8 months vs 12.1 months， P= 0.016). COX multivariate regression analysis showed that radiotherapy can be used as an independent prognostic factor for both PFS and OS in patients with SCLC(HR=0.488， 95%CI=0.303~0.787， P=0.003； HR=0.314， 95%CI=0.190~0.519， P=0.000. PLR level can be used as an independent prognostic factor for PFS in patients with SCLC (HR=1.538， 95%CI=1.040~2.274， P=0.031)， but not as an independent prognostic factor for OS (HR=1.323， 95%CI=0.883~1.982， P=0.175). Conclusion PLR can reflect the prognosis of patients with SCLC， but it cannot be used as an independent prognostic factor.

Key words： Platelet to lymphocyte ratio Small cell lung cancer Prognosis

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	Articles by authors
	WANG Li-wei
	WANG Jian-wei
	JIA Wei
	QIANG Wei
	XUE Mei
	MA Chao
	WEI Xiu-qin

Cite this article:

WANG Li-wei,WANG Jian-wei,JIA Wei, et al. Correlation between platelet/lymphocyte ratio and clinical prognosis of small cell lung cancer[J]. Electron J Metab Nutr Cancer, 2019, 6(2): 196-199.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11-9349/r.2019.02.008 OR http://182.92.200.144/EN/Y2019/V6/I2/196

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