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Abstract Objective To explore the effects of combined lifestyle guidance and early dietary fiber intervention on slow transit constipation. Methods 82 patients diagnosed with slow transit constipation at out-patient department of Daping Hospital， Army Medical University were prospectively included from October 2015 to November 2016. Dietary， exercise and constipation status were investigated. Lifestyle guidance was given via one-to-one interview. Oral intervention of dietary fiber complex was continuously given to each subject for 10days. Daily dietary intake and exercise amount of subjects were monitored by monthly telephone interview. One and six month after intervention beginning， follow-up was performed to evaluate constipation improvement， dietary intake， water consumption， exercise change， weekly stool frequency， stool consistency (Bristol Stool Score)， Patient Assessment of Constipation Symptoms score (PAC-SYM score). Results Among 82 patients， 7 subjects were lost to follow-up. Finally， data from 75 patients diagnosed with slow transit constipation was analyzed. The results showed that proportions of the following patient groups were elevated， including patients with balanced meat and vegetables， patients with combined whole grains and refined grains as their staple food， patients with 100-150g daily animal food consumption， patients with one share of daily fruit consumption， patients with 1，500-2，000ml daily water consumption and patients with regular exercise. Compared with baseline， the patient’s stool frequency increased significantly［(1.40±0.77) vs (3.67±1.20) vs (3.62±1.17)， both P<0.05］ at 1-mo and 6-mo. Meanwhile the defecate feeling demonstrated a significant reduction［(1.48±1.26) vs (1.13±1.24) vs (0.89±1.10) both P<0.05］ and Bristol scores increased remarkably［(1.99±1.34) vs (3.89±0.95) vs (3.87±0.99) both P<0.05］. The PAC-SYM scores had s significant reduction［(2.21±0.42) vs (1.43±0.57) vs (1.51±0.46) both P<0.05］. The clinical improvement rates reached 88.00% and 86.67%， respectively. Self-satisfaction rates were 85.33% and 80.00%， respectively. Conclusion As an integrative clinical measure， combined treatment with lifestyle guidance and early dietary fiber supplementation is effective to improve symptoms and satisfaction degree of patients with slow transit constipation.
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