Potential application of postbiotics in prevention and treatment of colorectal cancer
1Ding Chao ，2Chen Mingfei ，1Wang Hao
1Department of General Surgery Nanjing Drum Tower Hospital Nanjing 210000 Jiangsu China
2Medical School of Nanjing
University Nanjing 210000 Jiangsu China
Abstract：Postbiotics refer to preparation of inanimate microorganisms and / or their components that confers a health benefit on the
host mainly including the components of the microorganism itself such as cell wall cellular peptides and microbial metabolites.
Postbiotics have the advantages of fixed chemical structure safe and non - toxic properties due to inactivated microorganisms and
longer shelf life compared to probiotics prebiotics and synbiotic products. In recent years the incidence of colorectal cancer has
increased rapidly and the relationship between colorectal cancer and gut microbiota has been more studied. Gut microorganisms
interact with host cells in healthy intestines modulating energy acquisition metabolism and immune response. Dysbiosis occurs when
microbiota is disturbed by environment invasion of pathogenic microorganisms and other factors stimulating occurrence and development of
colorectal cancer. Studies have confirmed that some postbiotics such as short chain fatty acids exopolysaccharides and tryptophan
metabolites can exhibit anticancer activity through different mechanisms providing a new vision for the prevention and treatment of
colorectal cancer but the specific clinical feasibility and treatment strategies still need to be further explored. This review focuses on
the definition classification mechanism of postbiotics and its connection with colorectal cancer along with the latest research progress
at home and abroad providing a theoretical basis for the application in the prevention and treatment of colorectal cancer.
