血清肉碱与结直肠癌放疗患者肌肉减少及营养状况的相关性

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摘要目的探讨血清肉碱水平与结直肠癌放疗患者肌肉减少及营养状态的相关性。方法选取 2020 年 1 月至 2021 年 12 月河北省邯郸市中心医院收治的结直肠癌放疗患者 84 例作为病例组,其中血清肉碱水平≥39. 77 μmol / L(高水平组) 42 例,血清肉碱水平<39. 77 μmol / L(低水平组)42 例,同时选取同期健康体检者 61 例作为对照组。采用酶循环法测定血清游离肉碱水平,对病例组和对照组血清游离肉碱水平进行分析。分析病例组两组营养状态、肌肉状态;采用 Pearson 相关分析血清肉碱水平与结直肠癌放疗患者肌肉减少及营养状态的相关性。结果病例组血清游离肉碱水平显著低于对照组(P<0. 05);病例组中两组血清肉碱水平、行走速度、手握力、前白蛋白、股骨颈骨密度(BMD)、血红蛋白(Hb)、白蛋白(ALB)、总蛋白(TP)、骨骼肌指数(SMI)、瘦体组织指数(LTI)对比差异均具有统计学意义(P<0. 05);Pearson 相关性分析显示,血清肉碱水平与 SMI (r = 0. 676)、股骨颈 BMD(r = 0. 544)、行走速度( r = 0. 560)、手握力( r = 0. 609)、LTI( r = 0. 411)、TP( r = 0. 532)、前白蛋白( r = 0. 532)、ALB(r = 0. 623)、Hb(r = 0. 376)呈正相关(P<0. 05)。结论结直肠癌放疗患者血清肉碱水平呈高表达,其可作为结直肠癌放疗患者肌肉减少及营养状况的血清标志物。

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	岳亚玲
	江丽强
	田遂
	刘峥

关键词 ：血清肉碱水平, 结直肠癌, 骨骼肌指数, 营养状态

Abstract：Objective To investigate the correlation between serum carnitine levels and sarcopenia and nutritional status in colorectal cancer patients undergoing radiotherapy. Method A total of 84 patients with colorectal cancer radiotherapy who were treated in our hospital from January 2020 to December 2021 were selected as the case group including 42 cases with serum carnitine level ≥39. 77 μmol/ L high level group and serum carnitine level was lower than 39. 77 μmol / L are 42 cases low level group . and 61 cases of healthy subjects during the same period were selected as the control group. Serum free carnitine levels were determined by enzyme cycle method and serum free carnitine levels in the case group and control group were analyzed. The nutritional status and muscle status of the two groups in the case group were analyzed Pearson correlation was used to analyze the correlation between serum carnitine levels and sarcopenia and nutritional status in colorectal cancer radiotherapy patients. Result The serum free carnitine level in the case group was significantly lower than that in the control group P<0. 05 . In the case group the serum carnitine levels walking speed hand grip strength prealbumin femoral neck BMD hemoglobin Hb albumin ALB total protein TP skeletal muscle index SMI and lean body tissue index LTI were significantly different P<0. 05 Pearson correlation analysis showed that serum carnitine levels were significantly associated with SMI r = 0. 676 femoral neck BMD r = 0. 544 walking speed r = 0. 560 hand grip strength r = 0. 609 LTI r = 0. 411 TP r = 0. 532 prealbumin r = 0. 532 ALB r = 0. 623 and Hb r = 0. 376 were positively correlated P<0. 05 . Conclusion The serum carnitine level is highly expressed in patients with colorectal cancer radiotherapy which can be used as a serum marker for sarcopenia and nutritional status in patients with colorectal cancer radiotherapy.

Key words： Serum carnitine level Colorectal cancer Skeletal muscle index Nutritional status

收稿日期: 2022-03-15

基金资助:河北省医学科学研究重点课题计划(20150461)

通讯作者: 刘峥,电子邮箱:lzlivenor@163.com

引用本文:

岳亚玲,江丽强,田遂,刘峥. 血清肉碱与结直肠癌放疗患者肌肉减少及营养状况的相关性[J]. 肿瘤代谢与营养电子杂志, 2022, 9(4): 481-486.
Yue Yaling,Jiang Liqiang, Tian Sui, Liu Zheng. Correlation between serum carnitine and sarcopenia and nutrition status in colorectal cancer patients undergoing radiotherapy. Electron J Metab Nutr Cancer, 2022, 9(4): 481-486.