Research progress of probiotics in tumor immunotherapy
Tumor immunotherapy is a therapeutic method that uses the immune system to restore the body′s normal
anti?tumor immune response, to control and remove the tumor. Intestinal microbiota can maintain the homeostasis and the health
of the body by interacting with the host and play a crucial role in the process of human physiological activities. More and more
studies have found that intestinal microbiota affects the occurrence and development of tumors. And the disorders of intestinal
microbiota and potential mechanisms in patients with tumors have also been gradually analyzed. At the same time, the intestinal
flora of patients also plays a decisive role, it has been found that the regulation of immune response by intestinal microbiota may
directly affect the therapeutic effect of cancer in the process of tumor immunotherapy. Artificial intervention to change intestinal
microbiota can be used as a new strategy to improve the effect of tumor immunotherapy and achieve accurate and personalized
treatment of cancer in combination with conventional immunotherapy. The intervention measures include antibiotics, probiotics,
and so on. Among them, probiotics, a kind of safe and effective microecological agents, have great potential in tumor
immunotherapy used to interfere with intestinal microbiota, but more clinical data and mechanisms are still needed. This paper
introduces the relationship between intestinal microbiota with tumor and the research progress of probiotics in tumor
immunotherapy, which provides theoretical support for the application of probiotics and the mechanism of probiotics affecting
host health.
College of Food Science and Engineering, Hainan University, Haikou 570228, Hainan, China
Abstract：Tumor immunotherapy is a therapeutic method that uses the immune system to restore the body′s normal
anti⁃tumor immune response, to control and remove the tumor. Intestinal microbiota can maintain the homeostasis and the health
of the body by interacting with the host and play a crucial role in the process of human physiological activities. More and more
studies have found that intestinal microbiota affects the occurrence and development of tumors. And the disorders of intestinal
microbiota and potential mechanisms in patients with tumors have also been gradually analyzed. At the same time, the intestinal
flora of patients also plays a decisive role, it has been found that the regulation of immune response by intestinal microbiota may
directly affect the therapeutic effect of cancer in the process of tumor immunotherapy. Artificial intervention to change intestinal
microbiota can be used as a new strategy to improve the effect of tumor immunotherapy and achieve accurate and personalized
treatment of cancer in combination with conventional immunotherapy. The intervention measures include antibiotics, probiotics,
and so on. Among them, probiotics, a kind of safe and effective microecological agents, have great potential in tumor
immunotherapy used to interfere with intestinal microbiota, but more clinical data and mechanisms are still needed. This paper
introduces the relationship between intestinal microbiota with tumor and the research progress of probiotics in tumor
immunotherapy, which provides theoretical support for the application of probiotics and the mechanism of probiotics affecting
host health.
