The research progress of sarcopenia in elderly patients with chronic obstructive pulmonary disease
1Chengdu Medical College, Chengdu 610081, Sichuan, China; 2Collaborative Innovation Center of Sichuan for Elderly Care and Health, Chengdu 610500, Sichuan, China; 3National Clinical Research Center for Geriatrics/West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
Abstract：Abstract: As a chronic respiratory disease, chronic obstructive pulmonary disease occupies a high incidence in the elderly, while sarcopenia is one of the complications in COPD. For the past few years, many researches have reported cases that many elderly people attacked COPD have sarcopenia. We find that there is a high prevalence of sarcopenia among the elderly people when we set “sarcopenia” and “COPD&r; as keywords to search in CNKI, VIPI, Wang fang and pubmed. The risk factors in elderly patients of COPD with sarcopenia include: advanced-age, low-BMI, long-course, smoking. The pathophysiological mechanism of elderly COPD with sarcopenia is complicated, including the anabolism of muscle decreases and the catabolism of muscle increases, and the inflammatory factor, growth factor and hormone are the mainly reasons. Clinical features include: limited physical activity, slow gait, poor endurance at the same time the entire body is in a weak state. Clinical features include: limited physical activity, slow gait, poor endurance and the entire body in a weak state. Drug intervention strategies are still in the research stage, and other intervention strategies include: smoking cessation, reasonable exercise, strengthen nutrition. Eldery COPD patients with sarcopenia have reduced quality of life, increased hospitalization and mortality risk, and have a poor prognosis. Therefore, to prevent elderly's disability in early stage, it is significant to pay attention to eldery COPD with sarcopenia. This article reviews the epidemiology, risk factors, pathophysiological mechanisms, clinical features, diagnosis, intervention and prognosis of elderly COPD with sarcopenia.
2018, Vol. 5 
