Abstract：Objective To explore the significance of prognostic nutritional index PNI and serum soluble urokinase - type
plasminogen activator receptor suPAR and thymidine kinase 1 TK1 in the expression of advanced hepatocellular carcinoma and its
role in prognostic evaluation. Method A retrospective analysis was conducted on 92 patients with advanced liver cancer collected from
February 2019 to February 2021 all of whom underwent PNI evaluation and serum suPAR and TK1 detection. The levels of PNI
suPAR and TK1 were compared between the two groups. At the same time based on whether the patient died they were divided into
a poor prognosis group n = 28 death and a good prognosis group n = 64 survival . After analyzing the independent risk factors
affecting the prognosis of advanced liver cancer patients using a multi factor Cox risk model the diagnostic value of PNI suPAR and
TK1 was analyzed using receiver operating characteristic ROC curves. Result Through univariate analysis vascular invasion and
portal vein thrombosis can have an impact on the prognosis of advanced liver cancer P < 0. 05 and the PNI index of the poor
prognosis group is lower than that of the good prognosis group while the levels of suPAR and TK1 are higher than those of the good
prognosis group with statistically significant differences. Kaplan Meier survival analysis showed that patients with high expression of
PNI low expression of suPAR low expression of TK1 no vascular invasion and no portal vein thrombosis had significantly higher
survival time than those with low expression of PNI high expression of suPAR high expression of TK1 vascular invasion and portal
vein thrombosis with statistical significance P<0. 05 According to the multi factor Cox risk model analysis low expression of PNI
high expression of suPAR and high expression of TK1 are independent risk factors affecting the prognosis of advanced liver cancer
patients P<0. 05 . According to ROC curve analysis the area under the curve for PNI suPAR TK1 and the combined diagnosis of
advanced liver cancer prognosis were 0. 818 0. 827 0. 801 and 0. 957 respectively. Conclusion As serum suPAR and TK1 levels
increased PNI index decreased prognosis nutrition index suPAR and TK1 can be used as a simple and effective index to help
evaluate the severity and prognosis of patients with advanced HCC.
刘扬,车瑾,秦婷婷,曹蔚,张园园,徐洋. 预后营养指数及血清 suPAR、TK1 在晚期肝癌预后中的预测价值[J]. 肿瘤代谢与营养电子杂志, 2024, 11(1): 110-115.
Liu Yang，Che Jin，Qin Tingting，Cao Wei，Zhang Yuanyuan，Xu Yang. The predictive value of prognostic nutritional index，SUPAR and TK1 in the prognosis of advanced hepatocellular carcinoma. Electron J Metab Nutr Cancer, 2024, 11(1): 110-115.
