Gut flora intervention on sarcopenia in cancer patients
1Luo Xiaoqin,1Yang Hexiang,2Zhao Qingchuan
1
School of Public Health Xi'an Jiaotong University Xi'an Shaanxi China 710048
2Xijing Hospital of Gastroenterology the Fourth
Military Medical University Xi'an 710032 Shaanxi China
Abstract：Tumors are identified as key factors in secondary sarcopenia. Despite the ambiguity surrounding the precise mechanism
of sarcopenia in cancer patients an increasing array of research indicates that an imbalance in the gut microbiota may play a critical
role in this context. These microorganisms which influence energy metabolism and intestinal mucosal protection via the nervous
immune and endocrine systems may provide potential targets for sarcopenia's prevention and treatment in cancer patients. Current
interventions include fecal bacteria transplantation the introduction of probiotics prebiotics symbiotics or postbiotics and
modifications in diet. Despite some research limitations gut microbiota intervention is emerging as a new strategy to maintain muscle
mass and function by enhancing immunity regulating metabolism and reducing treatment side effects. This paper analyzes existing
studies reviews the relationship between intestinal microbiota intervention and sarcopenia in cancer patients outlines intervention
effects and provides directions for future research and treatment options. The available evidence strongly supports the potential role of
gut microbiota in treating and caring for cancer patients.
