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| Research progress on the mechanism and function of protein lactylation modification |
| 1Wang Anqi ,2 Yang Li ,3Zhao Le, 4 Li Min, 3Zhou Xin |
| 1School of Pharmaceutical Sciences Jilin University Changchun 130021 Jilin China
2Key Laboratory of Zoonosis Research Ministry of Education Institute of Zoonosis College of Veterinary Medicine Jilin University Changchun 130062 Jilin China
3The First Bethune School of Clinical Medicine Cancer Research Institute of Jilin University Jilin University Changchun 130021 Jilin China
4Pharmacological Experiment Center School of Pharmaceutical Sciences Jilin University Changchun 130021 Jilin China |
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Abstract Lactate the byproduct of glycolysis has long been considered as a waste metabolite. The discovery of Warburg effect in
cancer cells brought our attention back to lactate and inspired us to uncover the crucial roles of lactate in serving as fuel acting as a
signal molecule promoting angiogenesis and suppressing immune cells. However the mechanism regarding how lactate regulates these
biological processes remains elusive. As we known thousands of metabolites will be produced during life activities. They are not only
the products catalyzed by proteins enzymes but also can in turn affect the function of proteins through covalent modification. In 2019
and 2020 lactate was reported to be the substrate of lactylation by two independent studies and this novel post-translational modification revealed another layer of molecular mechanism by which lactate regulates cellular activities. In this review we briefly describe the
discovery of lactylation and we summarize the recent advances with respect to the potential writer and eraser of lactylation the
profiling of protein lactylation in a variety of organisms and the regulatory roles of lactylation in diverse physiological and pathological
processes. Key questions and potential implications for future studies on lactylation are also discussed.
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Received: 13 February 2022
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