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| The cause of cholesterol gallstones from the perspective of molecular biology |
| 1Zhang Pengyun, 1Xu Pengyuan, 1 Sun Yanbo, 2 Li Xiufen |
| 1Department of Gastrointestinal Surgery The Second Affiliated Hospital of KunMing Medical University Kunming 650000 Yunnan China
2Department of General Practice Community Health Center of Qujing Qujing 65500 Yunnan China |
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Abstract Gallstones are one of the most common digestive system diseases and the prevalence of cholesterol stones is increasing
year by year with people's lifestyle changes. The study of gallstones has gone deep into molecular biology. Research progress has been
made in many aspects such as genetic inheritance epigenetics and cell signal transduction and it has become a current research
hotspot. In this paper the origin of cholesterol gallstones is introduced in detail from the main lines of replication transcription and
translation. Introduced from genetic inheritance the substitution of bases in the process of ABCG5 / G8 gene replication finally affects
the translation of cholesterol transporter and finally affects the secretion of bile cholesterol. Insertion mutations in the ABCB4 gene
have an effect on the translation of bile salt transporter and bile salt secretion. Epigenetics is mainly reflected in the influence of various
microRNAs on the translation process. And the influence of various molecular signals in signal transduction on the translation process. The motor function of the gallbladder is an important reason for lithogenesis and genes such as the Cckar gene were found to regulate the movement of the gallbladder. In this paper the main lithogenic factors and mechanisms in genetic inheritance epigenetics and cell signal transduction will be expounded and the causes of cholesterol gallstones will be systematically expounded from the perspective of molecular biology.
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Received: 09 February 2022
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Corresponding Authors:
徐鹏远,电子邮箱:PengyuanXu1960@163.com
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