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| Protective effect of methyl nutrient containing betaine on kidney in patients with diabetic nephropathy and hyperhomocysteinemia |
| 1Zeng Yaochi，1Li Cuiyu，1Song Xiaoli，2Yuan Rui，3Ge Na，1Wei Wenting
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| 1Department of Nutrition Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033 Guangdong China
2Medical Laboratory
Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033 Guangdong China
3Nephrology Laboratory Shenzhen Traditional
Chinese Medicine Hospital Shenzhen 518033 Guangdong China |
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Abstract Objective To explore the effect of betaine-containing methyl nutrients on renal function and urinary microalbuminuria
MA in patients with diabetic kidney disease DKD accompanied by hyperhomocysteinemia HHcy . Method Sixty-four patients
with DKD and HHcy were recruited from Shenzhen Traditional Chinese Medicine Hospital between September 2019 to January 2021.
They were randomly divided into methyl nutrient group n = 21 and folate methylcobalamin group n = 32 . After 16 weeks of intervention the differences in blood glucose blood lipids renal function and MA and other indicators between the two groups were studied.
The treatment effect was represented by intention-to-treat analysis. Result Compared with the folate methylcobalamin group urea nitrogen UN serum creatinine Scr uric acid UA cystatin C Cys C homocysteine Hcy urine creatinine UCr MA β2
microglobulin Uβ2 -MG N- acetylglucosaminidase NAG total urinary protein TP -U and urinary albumin / creatinine ratio
ACR were significantly decreased in methyl nutrient group containing betaine. The increase of estimated glomerular filtration rate
eGFR and folic acid FA in estimated glomerular filtration rate in the methyl nutrient group containing betaine were better than the
folate methylcobalamin group with significantly significant differences. Conclusion HHcy may be one of the factors affecting the renal
function of patients with T2DM. The reasonable application of betaine-containing methyl nutrients can reduce Hcy levels effectively
protect renal function and reduce MA levels.
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| [1] |
Bone Health and Nutrition Branch of Chinese Nutrition Society, Chinese Society of Parenteral and Enteral Nutrition, North Chronic Disease Prevention and Treatment Branch of Chinese Geriatric Society. Expert consensus on hyperhomocysteinemia#br#[J]. Electron J Metab Nutr Cancer, 2020, 7(3): 283-288. |
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