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| Advances in the study of cytoglobin in inhibiting the transformation of non‑alcoholic steatohepatitis into hepatic cell carcinoma |
| 1Bai Yu，1Huang Feng，2,3Chao Xu |
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Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, Shaanxi, China; 2
Department of Pathology, Basic Medical College,
Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, Shaanxi, China; 3
Department of Biochemistry, Basic Medical College,
Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, Shaanxi, China |
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Abstract Cytoglobin（GYGB）, a stellate cell⁃specific globin, has recently become a hotspot protein due to its association
with liver fibrosis. The control of inflammation in tumor occurrence and development plays a quite important role in the process,
and the transformation of“inflammation⁃cancer”mechanism research in the field of cancer basic research has become a new
frontier, and the transformation of“inflammation⁃cancer”regulation network, molecular mechanism and signal pathway has
gradually become the main target of tumor prevention and treatment. This review mainly summarizes the potential functions of
globulin in the liver, including oxidative stress and signaling pathway transduction, and further discusses the inhibition of CYGB
in the transformation from non⁃alcoholic steatohepatitis to primary liver cancer in three aspects: inactivation of hepatic stellate
cells, increase of fat transport and resistance to oxidative stress. The study of“inflammation⁃cancer”transformation will provide
a new breakthrough for the prevention, diagnosis and treatment of primary liver cancer.
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Received: 04 September 2021
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