丝氨酸转运蛋白SFXN1在非小细胞肺癌中的表达及临床意义

doi:10.16689/j.cnki.cn11-9349/r.2020.03.010

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Abstract Objective To explore the expression of serine transporter SFXN1 and its relationship with stage and prognosis of non-small cell lung cancer. Methods Expression and prognostic implications of SFXN1 in lung cancer were analyzed by bioinformatics methods with databases including TCGA, Oncomine, HPA, UALCAN and Kaplan Meier plotter. Gene set enrichment analysis (GSEA) was used to explore the possible mechanism of SFXN1 regulating the oncogenesis, development and prognosis of lung cancer. Results Analysis with TCGA dataset showed that the expression level of SFXN1 in NSCLC was significantly higher than that in normal tissues. Statistics analysis of the gene sets in Oncomine showed that the expression of SFXN1 in lung adenocarcinoma was significantly higher than that in normal lung tissue, and the relative expression fold-change were 2.664 (P<0.001), 2.156 (P<0.001), 1.708 (P<0.001), 1.956 (P<0.001), 1.563 (P<0.001) and 1.653 (P<0.001), respectively. Compared with normal lung tissue, expression of SFXN1 protein in adenocarcinoma and squamous cell carcinoma was higher. The results of TCGA and UALCAN dataset showed that there was a positive relation between expression of SFXN1and clinical stage of lung adenocarcinoma；Kaplan Meier plotter analysis indicated that the expression of SFXN1 was negatively related to the prognosis of lung adenocarcinoma cases (median survival time, low expression group vs high expression group： 59.27 months vs 41.93months, P=0.0019). GSEA results suggested that the high expression samples of SFXN1 were enriched with E2F transcription factors, Myc signaling pathway, G2M checkpoint, mTORC1 complex, glycolysis, DNA damage repair and hypoxia related gene sets in lung adenocarcinoma. Conclusion SFXN1 is highly expressed in non-small cell lung cancer, and significantly related to the prognosis of lung adenocarcinoma patients. It may provide a new potential molecular marker and therapeutic target for the diagnosis and treatment of non-small cell lung cancer.

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	Articles by authors
	Jiang Huangang
	Luo Yuan
	Zhong Yahua
	Zhou Fuxiang
	Xie Conghua
	Chen Gaili

Cite this article:

Jiang Huangang,Luo Yuan,Zhong Yahua, et al. Expression and clinical significance of serine transporter SFXN1 in non-small cell lung cancer[J]. Electron J Metab Nutr Cancer, 2020, 7(3): 301-306.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11-9349/r.2020.03.010 OR http://182.92.200.144/EN/Y2020/V7/I3/301

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