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| Relationship between nutritional indicator and prognosis in advanced colorectal cancer undergoing chemotherapy |
| He Yanling1, Cai Hua1, Zhang Junling1, Su Jing 2, Yang Yuming1, Peng Ya1 |
| 1.Department of Gastroenterology, Hunan Provincial Peoples Hospital and the First Affiliated Hospital of Hunan Normal University， Changsha 410000, Hunan, China；2.Department of Head and Neck Internal Medicine， the Hunan Cancer Hospital， Changsha 410000， Hunan，China |
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Abstract Objective To explore the relationship between body mass index, hemoglobin, serum albumin, and prognosis in advanced colorectal cancer patients undergoing chemotherapy. Methods From January 2013 to January 2018, 97 patients with stage Ⅲ-Ⅳ colorectal cancer who underwent palliative operation and postoperative chemotherapy in Hunan cancer hospital were analyzed retrospectively. To collect the clinical pathological data and the results of nutritional indicator pre-and post-chemotherapy, analyze the changes and the effects of nutritional indicator pre-and post-chemotherapy, on the survival time of patients according to the follow-up data. Results ①Before chemotherapy, there was a statistically significant difference in age between overweight group and normal weight group, and overweight group and low weight group (P<0.001）. The difference in Hb levels between different tumor sites was statistically significant (P=0.029). ②After chemotherapy, patients with low weight and low Hb increased significantly, while patients with normal weight and high Hb decreased, the difference was statistically significant (P=0.017, 0.007). ③Gender、the levels of post-chemotherapy Hb and ALB on the prognosis of patients were statistically significant (P<0.05）. Tumor differentiation and post-chemotherapy BMI are independent risk factors that affect the prognosis of patients with colorectal cancer (P<0.05）.Conclusion ①Advanced colorectal cancer over 60 years of age is more prone to low weight, and patients with colorectal cancer were more prone to have anemia. ②The proportion of patients with low weight and anemia increased after chemotherapy, and the incidence of malnutrition was higher in patients with advanced colorectal cancer after chemotherapy. ③Gender、the levels of post-chemotherapy ALB and Hb are the risk factors for the prognosis of patients with advanced colorectal cancer, but cannot independently predict the prognosis. Tumor differentiation and post-chemotherapy BMI are independent risk factor for the prognosis of patients with advanced colorectal cancer after chemotherapy.
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Corresponding Authors:
彭娅，电子邮箱：pengyazjp@163.com
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