Ⅰ型子宫内膜癌组织中lncRNA-GAS5的表达及意义

doi:10.16689/j.cnki.cn11-9349/r.2020.01.008

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Abstract Objective To investigate the expression and significance of lncRNA-GAS5 in typeⅠendometrial cancer tissues. Methods Tissue samples were collected from 40 patients with typeⅠendometrial carcinoma and 40 patients with normal endometrial tissues for benign diseases such as uterine fibroids. The expression of lncRNAP-GAS5 in different endometrial tissues was detected by reverse transcription-polymerase chain reaction. And the detected data were combined with the clinicopathological data of patients with endometrial carcinoma for statistical analyses. Results Compared with normal endometrial tissues, the expression of lncRNA-GAS5 was down-regulated in typeⅠendometrial cancer tissues, and the difference between the two groups was statistically significant(P<0.05). The expression of lncRNAP-GAS5 in typeⅠendometrial cancer tissues of stage Ⅲ~Ⅳ was lower than that in endometrial cancer tissues of stage Ⅰ~Ⅱ. The relative expression quantity of lncRNAP-GAS5 in typeⅠ endometrial cancer with lymph node metastasis was lower than that in typeⅠendometrial cancer without lymph node metastasis with statistically significant(P<0.05). There was no difference in lncRNAP-GAS5 expression between different pathological grades, myometrial inva and ages of typeⅠendometrial carcinoma patients (P>0.05). Conclusions lncRNA-GAS5 was down-regulated in typeⅠendometrial cancer tissues,especially in typeⅠ endometrial cancer at advanced stage (Ⅲ~Ⅳ stage) and with lymph node metastasis, it may play an inhibitory role in the occurrence and metastasis of typeⅠendometrial carcinoma.

Key words： TypeⅠendometrial cancer Long noncoding ribonucleic acid-growth arrest-special transcript 5 Reverse transcription-polymerase chain reaction

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	Articles by authors
	1Qi Lining
	1Zhu Jihong
	1Guo Yanpu
	1Li Miao
	2Li Lin
	2Wei Xujing

Cite this article:

1Qi Lining,1Zhu Jihong,1Guo Yanpu, et al. The expression and significance of lncRNA-GAS5 in endometrial carcinoma tissues[J]. Electron J Metab Nutr Cancer, 2020, 7(1): 43-46.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11-9349/r.2020.01.008 OR http://182.92.200.144/EN/Y2020/V7/I1/43

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