单倍体造血干细胞移植患者移植前后营养状况动态变化

doi:10.16689/j.cnki.cn11－9349/r.2019.04.009

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Abstract ObjectiveTo explore the nutritional status of patients underwent haploid hematopoietic stem cell transplantation （HSCT） before and after transplantation, and to provide evidence for clinical nutritional intervention among post transplantation patients. Methods Forty-seven patients with hematological diseases received haploidentical allo-HSCT from July 2015 to June 2017 in the First Hospital of Jilin University were enrolled in present study. The patient-generated subjective global assessment （PG-SGA） and human component analysis were assessed before transplantation and 30, 90,180 days after transplantation respectively. ResultsThe body weight, body mass index （BMI）, fat-free mass, peripheral diameter of the left leg and mid-arm circumference decreased significantly at 30 days after transplantation, while fat mass increased but showed no statistical significance. Some indexes began to recover at 180 days after transplantation, but still lower than those before transplantation （all P<0.05）. According to the PG-SGA evaluation, malnutrition was as high as 95.56% in patients 30 days after transplantation, and recovered at 180 days after transplantation but still higher than those before transplantation （P<0.05）. In the early stage of transplantation, there were differences in weight and fat-free mass changes between men and women （P<0.05）. In particular, the proportion of weight loss in men at 30 days after transplantation was much higher than that in women, and men were more likely to have nutritional problems than women. ConclusionMalnutrition may occur in all patients after haploidentical allo-HSCT, and the nutritional assessment of the patients was more accurate and comprehensive by PG-SGA and human composition analysis.

Key words： Hematological diseases Haploid hematopoietic stem cell transplantation Nutritional assessment Human component analysis

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	Articles by authors
	JIA Yan-xue
	TAN Ye-hui
	GAO Su-jun
	LI Wei
	PENG Yi

Cite this article:

JIA Yan-xue,TAN Ye-hui,GAO Su-jun, et al. Changes of nutritional status in hematological patients before and after haploid hematopoietic stem cell transplantation[J]. Electron J Metab Nutr Cancer, 2019, 6(4): 436-441.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11－9349/r.2019.04.009 OR http://182.92.200.144/EN/Y2019/V6/I4/436

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