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Abstract When malignant tumors develop to the late stage， cancer cachexia (CC) is one of the most common complications. Its clinical symptoms are generally manifested as a decrease in muscle and bone mass， or a decrease in fat content， loss of appetite， and metabolic disorders， which lead to organ dysfunction. The study found that about one fifth of malignant tumor patients died from CC. The occurrence of CC has a serious impact on patients'lives， increasing treatment time， improving treatment cost， decreasing quality of life and reducing survival time. The pathogenesis of CC is complex. The known pathogenesis includes irreversible chronic inflammation induced by long-term stimulation of tumor tissue， the influence of inflammatory reaction on human metabolic balance， the inhibition of secretion of beneficial substances in central nervous system by inflammatory factors， and the reduction of appetite signals. At the present stage， some research results have been obtained on the pathogenesis of this disease. With the deepening of the research， we have a certain understanding of its therapeutic drugs. In view of its pathogenesis， the treatment of CC requires a variety of channels to work together， to give patients adequate nutrition and drug combination. This article from the current use of more appetite-stimulating drugs (progesterone， gastrin)， anti-inflammatory drugs (non-steroidal anti-inflammatory drugs， thalidomide， omega-3 fatty acids)， protein degradation inhibitors， metabolic regulators (androgen receptor regulators， beta-receptor blockers)analyzes the effect of the medication， and on the research progress of drug combination therapy is discussed.
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