乙酰辅酶A代谢与肿瘤转移

doi:10.16689/j.cnki.cn11-9349/r.2019.03.021

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Abstract Metastasis is an important hallmark of cancer and accounts for the majority of cancer-associated death. Cancer metastasis is regulated by multi-factors such as cancer cell itself and interactions between cancer cells and microenvironment. However， metastasis remains the most poorly understood component in cancer pathogenesis. Metabolic reprogramming is another important feature of cancer. Acetyl-CoA is a central metabolic intermediate， and plays a vital role in protein acetylation and lipid synthesis. Previous studies have shown that Acetyl-CoA metabolic alternation occurs in cancer progression， providing anabolic materials for the rapid proliferation of cancer cells. In recent years， several studies have reported close correlations between Acetyl-CoA metabolism alterations and tumor metastasis in several types of cancers， and have revealed the mechanisms underlying how Acetyl-CoA metabolic alterations promote cancer metastasis. This review will summarize recent progresses on the role Acetyl-CoA metabolic alteration in cancer metastasis from the following aspects: (1) brief introduction of the main metabolic pathways， key metabolic enzymes， and physiological roles of Acetyl-CoA metabolism;(2)Acetyl-CoA metabolism alterations regulate cancer metastasis by inducing epithelial-mesenchymal transition， cell adhesion and migration， and stemness of cancer cells;(3)future directions for the researches on the roles of Acetyl-CoA metabolism reprogramming in cancer metastasis.

Key words： Acetyl-CoA metabolism Cancer metastasis Protein acetylation Epithelial-mesenchymal transition Lipid synthesis

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	Articles by authors
	1
	2GAO Chao
	1
	2WANG Sheng-hao
	1
	2ZHU Wen-wei
	1
	2CHEN Jin-hong
	1
	2LU Ming
	1
	2
	3QIN Lun-xiu

Cite this article:

1,2GAO Chao,1, et al. Acetyl-CoA metabolism and cancer metastasis[J]. Electron J Metab Nutr Cancer, 2019, 6(3): 376-381.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11-9349/r.2019.03.021 OR http://182.92.200.144/EN/Y2019/V6/I3/376

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