ABD活性因子对肺癌患者化疗后骨髓抑制的作用研究

doi:10.16689/j.cnki.cn11-9349/r.2019.03.015

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Abstract Objective To explore the effect of ABD bioactives on myelosuppression alleviation in lung cancer patients during chemotherapy. Methods 44 lung cancer patients who received chemotherapy were randomly divided into intervention group and control group. 22 lung patients in intervention group received ABD Bioactives for adjuvant therapy. 22 lung cancer patients were treated conventionally. The difference of myelosuppression was compared between the two groups. Results 43 patients completed chemotherapy as planned， and 1 patients of the control group terminated chemotherapy due to severe myelosuppression. Myelosuppression of intervention group was significantly alleviated (P<0.05). The incidence of myelosuppression of Ⅲ~Ⅳ was significantly lower (P<0.05)， and the inhibition of leukocytes， granulocytes and platelets was significantly alleviated (P<0.05，P<0.05，P<0.05) compared with the control group. The myelosuppression induced by paclitaxel +platinum-based agents， pemetrexed+ platinum-based agents was significantly alleviated (P<0.05，P<0.05，P<0.05，P<0.05) compared with the control group. Conclusion ABD Bioactives can alleviate chemotherapy-induced myelosuppression in lung cancer patients， especially reduce the incidence of Myelosuppression of Ⅲ~Ⅳ， increase the levels of leukocytes， granulocytes and platelets， reduce the toxicity and side effects of platinum-based agents， paclitaxel， antimetabolite.

Key words： Myelosuppression ABD Bioactives Glutathione Nutritional therapy Clinical risk management

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	Articles by authors
	1*LUO Min
	2*WU Xiao-jun
	2ZHANG Xin
	3DONG Guang
	4XIONG Li-long
	4WANG Peng-cheng
	1GAO Kui
	1YU Ping
	1HE Mei
	5DU Chi
	5JIANG Ou
	6SHI Han-ping

Cite this article:

1*LUO Min,2*WU Xiao-jun,2ZHANG Xin, et al. ABD bioactives alleviates chemotherapy-induced myelosuppression[J]. Electron J Metab Nutr Cancer, 2019, 6(3): 346-350.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11-9349/r.2019.03.015 OR http://182.92.200.144/EN/Y2019/V6/I3/346

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