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Abstract Objective To explore the factors affecting the quality of life of surgical patients with primary hepatocellular carcinoma (PHC), and to provide evidence for clinical treatment and life intervention. Methods 364 cases of primary liver cancer admitted to the liver and cholecystectomy of Shanghai Ruijin Hospital between January 1, 2017 and October 31, 2018 were investigated by questionnaires and EORTC QLQC30. The factors affecting the quality of life of patients with primary liver cancer were analyzed by multiple linear regression analysis. Results Univariate analysis showed that age, education level, marital status, nutritional status, income, payment method, Child-Pugh grading of liver function and other factors had significant impact on the quality of life of patients with primary liver cancer (P<0.05). But sex and treatment methods had no obvious effect on the quality of life of liver cancer patients. Multivariate linear regression analysis showed that the education level, economic income, nutritional status of patients were positively correlated with quality of life score, while age, Child-Pugh grade of liver function were negatively correlated with quality of life score (P<0.05). Conclusion There are many factors affecting the quality of life of patients with hepatocellular carcinoma. In the course of treatment, positive and targeted interventions can effectively improve the quality of life of patients.
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1.魏矿荣, 彭侠彪, 梁智恒. 全球肝癌流行概况.中国肿瘤. 2015;24(8):621-630.
2.Gao LB, Tian H, Wang XG, et al. Early enteral and parenteral nutritional support after hepatectomy in patients with hepatic carcinoma: a systematic review and meta-analysis.Onco Targets Ther. 2015;8(8):623-631.
3.Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality of life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365-376.
4.万崇华, 陈明清, 张灿珍, 等. 肿瘤患者生命质量测定量表EORTC QLQ-C30中文版评介. 实用肿瘤杂志. 2005;20(4):353-355.
5.Takiar R, Nadayil D, Nandakumar A. World cancer report. Lyon: IARC. 2014:1-351.
6.陈万青. 从肿瘤登记数据看中国恶性肿瘤的发病特点和趋势. 中华健康管理学杂志.2016;10 (4):249-252.
7.朱建军, 刘英, 赵桐. 肝癌患者生活质量影响因素多元线性回归分析. 河北北方学院学报. 2014;30 (6):62-64.
8.赵丽萍. 原发性肝癌患者生活质量研究. 中国行为医学科学. 2013;12(6):639-641.
9.刘香艳, 曹文婷, 王毅欣. 肝癌患者生活质量测评工具及应用. 肿瘤. 2011;31(4):374-378.
10.乔秋阁, 李增宁, 游道锋, 等. 肝癌患者营养状况与生活质量相关性研究 . 护理实践与研究. 2016;13(18):111-113.
11.陈志玲, 江錦芳, 方桂香. 原发性肝癌患者的生存质量调查分析及护理干预 . 中国临床研究. 2016;29 (2):287-289.
12.Chen X, Liu HP, Li M, et al. Advances in nonsurgical management of primary liver cancer. World J Gastroenterol. 2014;20(44):16630-16638.
13.刘浩, 徐琴, 孙晓凤, 等. 中晚期肝癌介入治疗患者的生存质量及预后影响因素分析. 川北医学院学报. 2016;31(5):693-695.
14.张波, 李晓敏, 李巧芳, 等. 三维适形放疗联合肝动脉化疗栓塞术治疗中晚期肝癌临床研究. 胃肠病学和肝病学杂志. 2014;23(7):816-818.
15.术沈丹, 叶敏, 石玉丹. 益气化瘀消积方对中晚期肝癌患者生存质量的影响. 浙江中医杂志. 2016;51(5):319-320.
16.黄丁平, 白广德, 练祖平. 中药联合化疗在中晚期肝癌治疗中应用疗效观察. 中国伤残医学. 2014;22 (11):153-155.
17.Matsueda K, Yamamoto H, Umeoka F, et al. Effectiveness of endoscopic biliary drainage for unresectable hepatocellular carcinoma associated with obstructive jaundice. Gastroenterol. 2014;36(3):173-180.
18.祝葆华, 万崇华, 王坤, 等. FLIC、SF-36和QOL4C量表在肝癌患者生活质量测定中的应用比较. 中国循证医学杂志. 2012;12(10):1175-1179.
19.叶燕明, 黄艳庆, 黄玫英. 原发性肝癌患者生活质量调查. 现代医药卫生. 2010;26 (17):2564 -2565.
20.魏小燕. 肝癌患者生活质量影响因素分析. 内科. 2015;10 (5):674-676. |
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