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| Vitamin D3 and gastrointestinal tumor |
| ZHANG Yong-xin, CHEN Hao, XIONG Yong-qiang |
| First Hospital of Medical University, Taiyuan 03001, Shanxi, China |
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Abstract The structure of vitamin D3belongs to steroid hormone. Its main physiological function is regulating calcium and phosphorus metabolism and maintaining normal blood calcium levels, regulating bone metabolism and physiological reaction of many cells. In recent years, many studies have shown that vitamin D3plays an important role in many kinds of tumors, affecting tumor cell proliferation, apoptosis and other activities. The mechanisms by which vitamin D3acts on different cancer cell types strongly suggest that vitamin D3may play a protective and antitumor role, delaying cell transformation, proliferation, and cancer progression. Epidemiological studies have found that serum vitamin D levels are negatively correlated with the risk of gastrointestinal cancer, and serum vitamin D levels are positively correlated with the prognosis of patients with gastrointestinal cancer. Further studies have shown that vitamin D3can induce apoptosis, block cell cycle and inhibit proliferation of gastrointestinal cancer cells in a variety of ways. Vitamin D3 can cooperate with chemotherapeutic drugs to promote tumor cell apoptosis and inhibit tumor cell proliferation. Compared with vitamin D3, vitamin D3has less side effects and can play its role in inhibiting the growth of tumor cells. Vitamin D3may exert its antitumor effect through vitamin D3 receptor VDR. In combination with these studies, vitamin D3is expected to become a new approach for the treatment and prevention of gastrointestinal tumors, and more vitamin D3 anti-tumor mechanisms and clinical trials can bring good news for patients with gastrointestinal cancer.
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