|
|
|
| Nutrition intervention in advanced upper gastrointestinal cancer patients undergoing chemotherapy |
| XIN Xiao-wei, FANG Yu,GONG Li-qing |
| 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Clinical Nutrition, Peking University Cancer Hospital & Institute, Beijing 100142, China;
2Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China; 3Beijing Kancare Nutrition Technology Co., Ltd, Beijing 102206, China |
|
|
|
|
Abstract Objective To evaluate the effect of nutritional intervention on the nutritional status of patients with upper gastrointestinal cancer before and after chemotherapy. MethodsAdvanced upper gastrointestinal cancer patients (n=82) were screened and assessed by NRS 2002 and PG-SGA. According to the results of PG-SGA, the patients were divided into three groups: well-nourished (A), moderately malnourished or suspected of being malnourished (B) and severely malnourished (C). Nutritional intervention is based on the "five steps of malnutrition". Nutritional status, weight, energy and protein intakes of the patients were compared before and after chemotherapy. ResultsBefore intervention well-nourished patient was 10.98%(8/82), moderately malnourished or suspected of being malnourished was 50.00%(41/82), severely malnourished was 39.02%(32/82). The incidence of nutritional risk and malnutrition after intervention decreased, before intervention was 52.44% and 89.02% respectively, after intervention was 35.37% and 75.61% respectively. Compared to before chemotherapy, the weight of patients in well-nourished group and moderately malnourished or suspected of being malnourished group maintained stability, [(67.88±11.25) kg vs (67.22±10.17) kg, P>0.05 and (63.00±11.50) kg vs (62.58±11.48) kg, P>0.05], respectively. While in severely malnourished group, weight loss significantly [(59.92±9.61) kg vs (59.15±9.46) kg, P<0.05]. The average daily dietary intake of energy and protein increased significantly of moderately malnourished or suspected of being malnourished group and severely malnourished group, compared to before intervention (P<0.05) well-nourished group maintained stability (P>0.05). ConclusionsNutritional intervention can reduce the incidence of nutritional risk and malnutrition of patients with advanced upper gastrointestinal cancer, decrease weight loss, improve nutritional status, and may help to improve the clinical outcome.
|
|
|
|
|
|
| [1] |
SHI Han-ping， LIANG Xiao-xiao. Analysis of nutritional status of hospitalized patients with type 2 diabetes mellitus[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(3): 342-345. |
| [2] |
1YAO Ke-qing， 1WANG Su， 1CHEN Shuang， 1SUN Yan-teng， 1LIU Qing-yang， 1CHEN Tao，1LIU Xue-hui， 2CONG Ming-hua. Application of individualized nutrition diagnosis and intervention in patients with advanced cancer[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(3): 305-309. |
| [3] |
1LIU Yong-bo，2，3DENG Li， 1GUO Yi-hui，1LI Yan-ping. Atg13 gene overexpression induces chemotherapy resistance in triple-negative breast cancer cells[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(3): 310-315. |
| [4] |
1，2GENG Bi-zhu, 1ZHENG Jin. Review of family nutrition support research during the intermission of chemotherapy[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(3): 386-390. |
| [5] |
SHENG Xiang， LI Su-yi. Advances in research on intestinal microecology and clinical outcomes of tumors[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(2): 178-182. |
| [6] |
ZIWAREGULI Nur, FANG Ruo-xin，LIAO Zheng-kai. The correlation between intestinal microecology and the efficacy of chemotherapy[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(2): 161-166. |
|
|
|
|
