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| The value of bone turnover biomarkers and tumor marker in the diagnosis of bone metastasis in breast cancer |
| Xiong Bingjun,Huang Jing,Yuan Keyu,Lyu Shuzhen,Li Yanping |
| Department of Breast Center Beijing Shijitan Hospital Capital Medical University Beijing 100038 China |
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Abstract Objective To explore the diagnostic value of ICTP Tracp 5b and CA15-3 in bone metastasis of breast cancer. Method
A retrospective review was performed in 87 breast cancer and 25 breast benign diseases the breast cancer patients were divided into 3
groups 32 patients with bone metastasis 35 patients with no metastasis and 20 patients with extraosseous metastasis. The serum levels
of serum ICTP Tracp 5b and CA15 - 3 in 87 patients with breast cancer and 25 patients with benign tumor were measured by
enzyme-linked immunosorbent assay ELISA and chemiluminescence immunoassay CLISA . Result The serum levels of ICTP
Tracp 5b and CA15-3 were significantly increased in the bone metastasis group P < 0. 05 . The sensitivity specificity positive
predictive value and negative predictive value of the parallel combined detection of serum ICTP Tracp 5b and CA15-3 in the diagnosis
of bone metastasis of breast cancer were 96. 88% 76. 36% 70. 45% and 97. 67% respectively. The sensitivity of parallel combined
detection is significantly greater than ICTP Tracp 5b and CA15-3 P<0. 05 . The sensitivity specificity positive predictive value
and negative predictive value of the parallel combined detection were 37. 50% 98. 18% 92. 31% and 72. 97% respectively. The
specificity of parallel combined detection is significantly greater than ICTP Tracp 5b and CA15-3 P<0. 05 . Joint diagnosis is more
effective than independent diagnosis of the three. Conclusion The detection of serum ICTP Tracp 5b and CA15-3 can significantly
improve the diagnostic efficiency of bone metastasis in breast cancer and can be used as an effective laboratory index to assist imaging
diagnosis of bone metastasis in breast cancer.
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Received: 16 March 2022
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