|
|
|
| The role and potential therapeutic value of tumor-associated macrophages in colorectal cancer |
| 1Xu Shaoqiang,1Liu Chengfei,2Yao Tian,2Huang He |
| 1First Clinical Medical School of Shanxi Medical University Taiyuan 030001 Shanxi China
2Department of General Surgery First
Hospital of Shanxi Medical University Taiyuan 030001 Shanxi China |
|
|
|
|
Abstract Colorectal cancer CRC is a common malignant tumor of the digestive system and its occurrence and development are
not only related to the characteristics of tumor cells themselves but also closely related to the tumor microenvironment TME . As an
important component of TME tumor-associated macrophages TAMs regulate a variety of key oncogenic processes in CRC promote
tumor genesis proliferation and metastasis by secreting cytokines and chemokines and coordinating with inflammatory
mechanisms. Based on the impact of TAMs on tumor progression the current therapeutic strategies targeting tumor macrophages mainly
focus on TAMs as targets for immunotherapy inhibition of macrophage recruitment reinduction of phenotypic polarization of TAMs
and combination of TAMs targeted therapy with conventional treatment. Therefore the growing understanding of the functional and
regulatory mechanisms of TAMs will allow us to effectively explore their clinical application in colorectal cancer. In this review we
describe the role and related mechanisms of TAMs in the occurrence and progression of colorectal cancer and based on the above
summarize the potential therapeutic strategies for colorectal cancer related to TAMs so as to provide emerging treatment ideas and
methods for the diagnosis and treatment of CRC which has effective reference value.
|
|
Received: 11 December 2022
|
|
|
|
|
|
|
