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| Traditional Chinese medicine enhances the role of high-dose vitamin C in treating tumors |
| Qu Jinxiu, Wang Xin, Rao Benqiang |
| Department of Gastrointestinal Surgery Beijing Shijitan Hospital Capital Medical University Key Laboratory of Cancer FSMP for State
Market Regulation Beijing 100038 China |
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Abstract High-dose vitamin C HVC therapy for tumors is essentially a metabolic modulation that treats tumors by regulating
tumor and body metabolic reprogramming through mechanisms such as pro -oxidative stress epigenetic modifications immune and
oxygen-sensing modulation. Traditional Chinese medicine TCM has the natural advantage of multi-target and multi-path to regulate
the complex metabolic network of the body and tumor. Through treatment based on pattern differentiation and "state-target" treatment
it can realize the spatial and temporal synergistic regulation between the body and tumor. Research shows that the original pathogenesis
of tumor "deficiency toxicity and stasis" can be analogous to the metabolic disorders of tumor energy flow material flow and drainage
flow and HVC treatment for tumor interferes with the pathogenesis of tumor "deficiency toxicity and stasis" at the same time. The
anti-tumor Heat - clearing and Detoxifying Blood - activating and Stasis - eliminating and the Body resistance - strengthening and
consolidating drugs have regulatory effects on tumor mitochondrial metabolism lipid metabolism and amino acid metabolism
respectively and TCM can strengthen the effect of HVC for tumor treatment from multiple perspectives such as pro-oxidative stress
induction of ferroptosis and inhibition of mitochondrial respiration. Based on the theory of the metabolic reprogramming of tumor "
deficiency toxicity and stasis" and "state - target" treatment based on pattern differentiation this paper interprets the theoretical basis
of HVC treatment fortified with TCM for tumors and condenses the possible targets and synergistic treatment protocols of HVC
treatment fortified with TCM for tumors providing new ideas for TCM combined with HVC treatment for tumors.
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Received: 01 March 2023
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