|
|
|
| Function of long-chain acyl-CoA synthetases family and the research progress in tumors |
| 1Zhang Lin ，2Wu Bo ，3Wang Dongwen |
| 1First Clinical Medical College of Shanxi Medical University Taiyuan 030001 Shanxi China
2Department of Urology First Hospital of
Shanxi Medical University Taiyuan 030001 Shanxi China
3Department of Urology National Cancer Center/ National Clinical Research
Center for Cancer/ Cancer Hospital & Shenzhen Hospital Chinese Academy of Medical Sciences and Peking Union Medical College
Shenzhen 518116 Guangdong China |
|
|
|
|
Abstract Fatty acids are essential nutrients to maintain normal physiological functions in the body and need to be activated by
relevant enzymes in the body before they enter the normal metabolic pathway. While dysregulation of fatty acid metabolism is closely
associated with tumorigenesis. Long - chain acyl - CoA synthases ACSLs are responsible for the activation of long - chain fatty
acids. The ACSLs family consists of five members ACSL1 ACSL3 ACSL4 ACSL5 and ACSL6 with different isoforms having
different cellular localizations which can catalyze different lipids and influence their metabolic routes. ACSLs are extensively involved in
endoplasmic reticulum stress iron death drug resistance and tumor inflammatory microenvironment by regulating fatty acid
metabolism. And ACSLs are often deregulated in tumors and can affect fatty acid metabolism. However fatty acids can activate different
ACSLs by activating multiple transcription factors in combination with gene response elements and tumor cells and protein
ubiquitination can regulate the expression of ACSLs genes. This leads to the development of metabolic disorders in tumors and other
metabolic diseases. Triacsin C an inhibitor of ACSLs has great potential for the development of antitumor drugs. This article reviews
the expression and localization of ACSLs in cells physiological functions functions in tumors and molecular mechanisms. The results
indicate that ACSLs are associated with inflammatory response lipid metabolism disorders tumor invasion and metastasis in tumors
which are important for tumor development and may become valuable biomarkers and therapeutic targets for tumor therapy.
|
|
|
|
|
|
|
|
|
