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Abstract Objective To investigate the relationship between nucleolar spindle - associated protein 1 NuSAP1 low - density
lipoprotein receptor LDLR and axillary lymph node metastasis in patients with locally advanced breast cancer and analyze the risk
factors for axillary lymph node metastasis ≥ 10. Method A total of 125 patients with locally advanced breast cancer who were
diagnosed and treated in our hospital from January 2018 to April 2022 were selected as the research subjects. The tumor tissues and
adjacent tissues were collected during operation and the expressions of NuSAP1 mRNA and LDLR mRNA were detected. The
expressions of NuSAP1 mRNA and LDLR mRNA in cancer tissues of patients with different axillary lymph node metastasis were
compared. The correlation between NuSAP1 mRNA and LDLR mRNA expression and axillary lymph node metastasis was
analyzed. Binary Logistic regression model was used to analyze the risk factors of axillary lymph node metastasis ≥ 10. Result The
expressions of NuSAP1 mRNA and LDLR mRNA in cancer tissues were higher than those in adjacent tissues P< 0. 05 . With the
increase in the number of axillary lymph node metastases the expression of NuSAP1 mRNA and LDLR mRNA in cancer tissues
increased P<0. 05 . The expression of NuSAP1 mRNA and LDLR mRNA in cancer tissue was positively correlated with the number of
axillary lymph node metastasis P<0. 05 . After adjusting for clinical stage and maximum tumor diameter high expression of NuSAP1
mRNA and LDLR mRNA in cancer tissue were still independent risk factors for axillary lymph node metastasis ≥ 10 in breast cancer
patients P<0. 05 . Logistic regression model was established logit P = -6. 004+ 1. 298×LDLR mRNA+ 1. 141×NuSAP1 mRNA.
Conclusion NuSAP1 mRNA and LDLR mRNA expressed highly in cancer tissues of patients with locally advanced breast cancer and
the expression levels are closely related to the number of axillary lymph node metastases in patients.
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| Cite this article: |
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1Chen Xinkuan,1Yang Haiyan,2Liang Wei. The relationship between NuSAP1 LDLR and axillary lymph node metastasis in patients with locally advanced breast cancer
and its risk factors analysis[J]. Electron J Metab Nutr Cancer, 2022, 9(6): 747-752.
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| URL: |
| http://182.92.200.144/EN/ OR http://182.92.200.144/EN/Y2022/V9/I6/747 |
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