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| A review of amino acid metabolism in triple negative breast cancer |
| Liu Xinran, Liu Peng |
| Department of Clinical Nutrition Peking University People's Hospital Beijing 100044 China |
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Abstract Triple-negative breast cancer is a subtype of breast cancer that lacks the expression of estrogen receptor progesterone
receptor and human epidermal growth factor receptor 2. Its clinical characteristics are high degree of deterioration easy recurrence
high metastasis rate and low survival rate. This kind of breast cancer accounts for 15% - 20% of all breast cancer cases and the
treatment lacks effective targets. Metabolic abnormality is one of the important characteristics of tumor diseases. Therefore analyzing
the characteristics of triple-negative breast cancer from metabolic pathway is a new direction of personalized nutritional therapy. Recent
studies have found that the metabolism of nutrients especially amino acids in triple-negative breast cancer cells is different from
normal cells and is also different from other subtypes of breast cancer cells. This paper reviews the characteristics of amino acid
metabolism and related regulatory mechanisms in triple-negative breast cancer cells. It is found that the levels of glutamate / glutamine
cystine / cysteine methionine glycine serine and tryptophan are different from normal cells or other types of tumor cells and the
transformation and transport of amino acids are also in an abnormal regulatory state. Based on this characteristic regulating the
corresponding metabolic pathway by limiting the target amino acids may have a good effect on the treatment of triple-negative breast
cancer. At present nutrition deprivation has become an adjuvant treatment strategy for cancer cells. The in - depth study of the
metabolic characteristics of the disease is of great significance for finding the target of nutrition therapy.
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Received: 23 May 2022
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