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| Application of tumor metabolism in the treatment of solid tumors by chimeric antigen receptor T cells |
| 1Zhao Tingyu， 2Rezhayiding Niyazi， 1 Liu Lingxiang |
| 1Department of Oncology The First Affiliated Hospital of Nanjing Medical University Nanjing 210000 Jiangsu China
2Department of Oncology Xinjiang Yili Friendship Hospital Yili Kazak Autonomous Prefecture 835000 Xinjiang China |
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Abstract CAR-T cell therapy is a cutting-edge effective and rapidly evolving adoptive cell immunotherapy that recognizes tumor
cell surface antigens independently of major histocompatibility complexes thereby reducing immune escape due to loss of tumor cell
MHC-associated antigen presentation. Although it has been applied in blood cancer and made remarkable achievements its application
in solid tumors is still affected by some adverse factors. Metabolism is one of the detrimental factors a set of basic cellular processes
that not only sustain cell survival and proliferation but also serve as a means for cells to adapt to their local environment. Massive
competition for nutrients such as carbohydrates and amino acids generated by tumor cell metabolism in the tumor microenvironment
coupled with immunosuppression leads to mitochondrial dysfunction failure and subsequent CAR-T cell depletion leading to failure of
CAR-T cell therapy. Elucidating cellular intrinsic and extrinsic factors that inhibit CAR-T cell function in solid tumors will facilitate
the development of immunotherapy to establish a more durable and effective response in patients. In this review we briefly review the
application of tumor metabolism-related immunosuppressive factors in CAR-T cell therapy as well as recent advances and strategies to
improve the metabolic adaptability and antitumor activity of CAR-T cells in vivo and in vitro.
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Received: 15 March 2022
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