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| The prognostic value of nutritional index in patients with esophageal cancer surgery and its correlation with systemic inflam⁃
matory response markers |
| Miao Yan, Yin Hong, Li Shanshan, Wang Fang, Gao Jiajing, Zhou Hong, Leng Xuefeng，Han Yongtao |
| Division of Thoracic Surgery, Sichuan Cancer Hospital. Research Institute· Cancer Prevention and Treatment Center of Sichuan Province,
Chengdu 610041，Sichuan，China |
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Abstract Objective To investigate the prognostic significance of prognostic nutritional index in patients with esophageal
squamous cell carcinoma (ESCC) surgery and its correlation with systemic inflammatory response markers. Methods A
retrospective analysis of the clinical data of patients with esophageal squamous cell carcinoma who underwent radical esophageal
cancer surgery at Sichuan Cancer Hospital from December 2017 to October 2018. And calculate the patient′s prognostic
nutritional index (PNI), neutrophil⁃to⁃lymphocyte ratio (NLR), lymphocyte⁃to⁃monocyte ratio (LMR), platelet⁃to⁃lymphocyte ratio
(PLR) and other indicators. Spearman was used to analyze the correlation between PNI and systemic inflammatory response
markers, and Kaplan⁃Meier survival curve and Cox proportional hazard regression model were used to analyze the impact of
different PNI levels on the prognosis of patients with esophageal squamous cell carcinoma surgery. Results PNI was positively
correlated with LMR (R=0.514, P<0.001), and negatively correlated with NLR (R=-0.401, P<0.001) and PLR (R=-0.591, P<
0.001). Univariate analysis showed that age (P=0.13), LMR (P=0.004), NLR (P=0.018), PNI (P=0.017) were significantly related
to the patient′s OS. Further multivariate analysis showed that age (OR=1.676, 95%CI=1.056-2.661, P=0.028) and PNI (OR=
0.589, 95%CI=0.370-0.939, P=0.026) are independent prognostic factors of OS. PNI≥45.26 and age<65 years old indicate a
better prognosis for patients undergoing radical esophageal cancer surgery. Conclusion PNI is an important predictor of survival
outcome for patients with esophageal squamous cell carcinoma undergoing radical resection of esophageal cancer. It has certain
clinical value.
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Received: 20 January 2021
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| Cite this article: |
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Miao Yan,Yin Hong,Li Shanshan, et al. The prognostic value of nutritional index in patients with esophageal cancer surgery and its correlation with systemic inflam⁃
matory response markers[J]. Electron J Metab Nutr Cancer, 2021, 8(3): 274-278.
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| URL: |
| http://182.92.200.144/EN/ OR http://182.92.200.144/EN/Y2021/V8/I3/274 |
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