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| Research of Chinese medicine for activating blood circulation in regulating tumor metabolism |
| Tumor metabolism is characterized by aerobic glycolysis with metabolic disorder of amino acid and lipid, which is
the solid foundation of tumorigenesis. The special metabolic pattern can not only support the rapid growth of cancer, but also benefit
tumor from the hypoxia and acidic surrounding environment, contributing to induce gene mutation, promote proliferation and metastasis
and suppress immunity, which provides a proper condition to tumor development.Tumor metabolism becomes recent hotspot in research
correspondingly. Blood stasis is a common syndrome of traditional Chinese medicine among advanced cancer patients. The pathological
mechanism of blood stasis is similar to metabolic disorder. Thus, the mechanism of activating blood circulation in treating cancer was
considered to be related to regulate tumor metabolism. Researches report that Chinese medicine for activating blood circulation could
regulate the activities of metabolic enzymes and metabolic pathway?related proteins, affect mitochondrial function, reduce the intake
of nutrients such as glucose in cancer cells, inhibit aerobic glycolysis, reduce lactic acid production, change the hypoxic environment
of tumors, and inhibit angiogenesis, which provide evidence for the mechanism of Chinese medicine for activating blood circulation
regulating tumor metabolism. In this paper, the mechanism of traditional Chinese medicine activating blood drugs in treating tumor
was reviewed and discussed via regulating tumor metabolism, which contributes to elucidating the anti?tumor mechanism of activating
blood drugs, provides a new direction for the further research and guide the application of Chinese medicine for activating blood
circulation in tumor treatment. |
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Abstract Tumor metabolism is characterized by aerobic glycolysis with metabolic disorder of amino acid and lipid, which is
the solid foundation of tumorigenesis. The special metabolic pattern can not only support the rapid growth of cancer, but also benefit
tumor from the hypoxia and acidic surrounding environment, contributing to induce gene mutation, promote proliferation and metastasis
and suppress immunity, which provides a proper condition to tumor development.Tumor metabolism becomes recent hotspot in research
correspondingly. Blood stasis is a common syndrome of traditional Chinese medicine among advanced cancer patients. The pathological
mechanism of blood stasis is similar to metabolic disorder. Thus, the mechanism of activating blood circulation in treating cancer was
considered to be related to regulate tumor metabolism. Researches report that Chinese medicine for activating blood circulation could
regulate the activities of metabolic enzymes and metabolic pathway⁃related proteins, affect mitochondrial function, reduce the intake
of nutrients such as glucose in cancer cells, inhibit aerobic glycolysis, reduce lactic acid production, change the hypoxic environment
of tumors, and inhibit angiogenesis, which provide evidence for the mechanism of Chinese medicine for activating blood circulation
regulating tumor metabolism. In this paper, the mechanism of traditional Chinese medicine activating blood drugs in treating tumor
was reviewed and discussed via regulating tumor metabolism, which contributes to elucidating the anti⁃tumor mechanism of activating
blood drugs, provides a new direction for the further research and guide the application of Chinese medicine for activating blood
circulation in tumor treatment.
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Received: 30 September 2020
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Corresponding Authors:
zhoutian
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