抑郁对鼻咽癌放疗患者营养状况的影响

doi:10.16689/j.cnki.cn11-9349/r.2020.02.013

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Abstract Objective To evaluate the effect of depressive symptoms on the nutritional status of patients with nasopharyngeal carcinoma receiving radiotherapy. Methods According to the evaluation results of the HAD scale before radiotherapy， 77 patients with nasopharyngeal carcinoma who met the inclusion criteria were divided into the depressive group and the non-depressive group. Observe and evaluate the nutritional status changes of depression group （n=32） and non-depression group （n=45） before radiotherapy and the end of radiotherapy， and analyze the effect of depression on the nutritional status of patients. Results In this study， we found that about 41.6% of patients had depressive symptoms before radiotherapy. The average serum albumin and hemoglobin levels in the depression group at the end of radiotherapy were significantly lower than those in the non-depression group［（38.5±5.8） mg/dl vs （41.0±5.2） mg/dl，P=0.045；（108.3±31.6）g/L vs （111.6±16.6）g/L，P=0.041］， patients in depression group were more prone to weight loss ≥5%， BMI<18.5kg/m2 and NRS 2002 score ≥3 （75.0% vs 33.3%）， P=0.001； 28.1% vs 8.9%， P=0.026； 46.9% vs 17.8%， P=0.006）. Conclusion The depressive symptoms of patients with nasopharyngeal carcinoma are closely related to their nutritional status. In patients with nasopharyngeal carcinoma receiving radiotherapy， depressive symptoms may be used as predictors of malnutrition.

Key words： Nasopharyngeal carcinoma Depressive symptoms Nutritional status Radiotherapy

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	Articles by authors
	Zheng Xianbin
	Gao Jin
	Hua Lei
	Guo Weiqian2
	Tao Zhenchao
	Zhang Yangyang

Cite this article:

Zheng Xianbin,Gao Jin,Hua Lei, et al. Effect of depression on nutritional status of patients with nasopharyngeal carcinoma receiving radiotherapy[J]. Electron J Metab Nutr Cancer, 2020, 7(2): 204-208.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11-9349/r.2020.02.013 OR http://182.92.200.144/EN/Y2020/V7/I2/204

1.ZHANG S W， CHEN W Q， KONG L Z， et al.Morbidity and mortality of malignant tumors during 1998-2002 in China ［Chinese］［J］.China Cancer， 2010， 19: 356-365.
2.HOWREN M B， CHRISTENSEN A J， KARNELL L H， et al.Health-related quality of life in head and neck cancer survivors: impact of pretreatment depressive symptoms［J］.Health Psychol， 2010， 29 （1）: 65-71.
3.MASSIE M J.Prevalence of depression in patients with cancer［J］.J Natl Cancer Inst Monogr， 2004， 32: 57-71.
4.LAZURE K E， LYDIATT W M， DENMAN D， et al. Association between depression and survival or disease recurrence in patients with head and neck cancer enrolled in a depression prevention trial［J］. Head Neck， 2009， 31（7）: 888-892.
5.HORNEY D J， SMITH H E， MCGURK M，et al.Associations between quality of life， coping styles， optimism， and anxiety and depression in pretreatment patients with head and neck cance［J］.Head Neck， 2011， 33（1）: 65-71.
6.KIM S A， ROH J L， LEE S A，et al.Pretreatment depression as a prognostic indicator of survival and nutritional status in patients with head and neck cancer［J］. Cancer， 2016， 122（1）: 131-140.
7.BRITTON B， CLOVER K， BATEMAN L，et al.Baseline depression predicts malnutrition in head and neck cancer patients undergoing radiotherapy［J］.Support Care Cancer， 2012， 20（2）: 335-342.
8.KATZ M R， KOPEK N， WALDRON J，et al.Screening for depression in head and neck cancer［J］. Psychooncology， 2004， 13（4）: 269-280.
9.LARSSON M， HEDELIN B， JOHANSSON I， et al.Eating problems and weight loss for patients with head and neck cancer: a chart review from diagnosis until one year after treatment［J］.Cancer Nurs， 2005， 28（6）: 425-435.
10.BJELLAND I， DAHL A A， Haug T T，et al.The validity of the Hospital Anxiety and Depression Scale. An updated literature review［J］. J Psychosom Res， 2002， 52（2）: 69-77.
11.Daudt H M， Cosby C， Dennis D L，et al. Nutritional and psychosocial status of colorectal cancer patients referred to an outpatient oncology clinic［J］. Support Care Cancer， 2012， 20（7）: 1417-1423.
12.Nho J H， Kim S R， Kwon Y S，et al.Depression and appetite: predictors of malnutrition in gynecologic cancer［J］. Support Care Cancer， 2014， 22（11）: 3081-3088.
13.Tian J， Chen Z C， Hang L F，et al.Effects of nutritional and psychological status of the patients with advanced stomach cancer on physical performance status［J］.Support Care Cancer， 2009， 17（10）: 1263-1268.
14.BRITTON B， CLOVER K， BATEMAN L，et al.Baseline depression predicts malnutrition in head and neck cancer patients undergoing radiotherapy［J］. Support Care Cancer， 2012， 20（2）: 335-342.
15.Maes M， Bosmans E， De Jongh R，et al.Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression［J］. Cytokine， 1997， 9（11）: 853-858.
16.HOWREN M B， LAMKIN D M， SULS J， et al.Associations of depression with C-reactive protein， IL-1， and IL-6: a meta-analysis［J］.Psychosom Med， 2009， 71（2）: 171-186.
17.ALLAVENA P， SICA A， SOLINAS G，et al.The inflammatory micro-environment in tumor progression: the role of tumor- associated macrophages［J］.Crit Rev Oncol Hematol， 2008， 66（1）: 1-9.
18.MESSAY B， LIM A， MARSLAND A L，et al.Current understanding of the bidirectional relationship of major depression with inflammation［J］.Biol Mood Anxiety Disord， 2012， 2: 4.
19.MILLER A H， ANCOLI-ISRAEL S， Bower J E， et al.Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer［J］.J Clin Oncol， 2008， 26（6）: 971-982.
20.STETLER C， MILLER G E.Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research［J］.Psychosom Med， 2011， 73（2）: 114-126.
21.BHAGWAGAR Z， HAFIZI S， COWEN P J.Increased salivary cortisol after waking in depression［J］. Psychopharmacology （Berl）， 2005， 182（1）: 54-57.
22.HUBER T J， ISSA K， SCHIK G，et al.The cortisol awakening response is blunted in psychotherapy inpatients suffering from depression［J］. Psychoneuroendocrinology， 2006， 31（7）: 900-904.
23.MILLER A H， ANCOLI-ISRAEL S， Bower J E，et al.Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer［J］. J Clin Oncol， 2008， 26（6）: 971-982.
24.SCHREPF A， THAKER P H， GOODHEART M J，et al.Diurnal cortisol and survival in epithelial ovarian cancer［J］.Psychoneuroendocrinology， 2015， 53: 256-267.
25.SEPHTON S E，SAPOLSKY R M，KRAEMER H C，et al.Diurnal cortisol rhythm as a predictor of breast cancer survival［J］. J National Cancer Institute， 2000， 92（12）: 994-1000.
26.SEPHTON S E， LUSH E， DEDERT E A，et al.Diurnal cortisol rhythm as a predictor of lung cancer survival［J］. Brain Behav Immun， 2013， 30: 163-170.
27.PINQUART M， DUBERSTEIN P R.Duberstein， Depression and cancer mortality: a meta-analysis［J］. Psychol Med， 2010， 40（11）: 1797-1810.
28.SATIN J R， LINDEN W， PHILLIPS M J.Depression as a predictor of disease progression and mortality in cancer patients: a meta-analysis［J］.Cancer， 2009， 115（22）: 5349-5361
29.AHN S H， PARK B W， NOH D Y，et al.Health-related quality of life in disease-free survivors of breast cancer with the general population［J］. Ann Oncol， 2007， 18（1）: 173-182.
30.SHINN E H， VALENTINE A， JETHANANDANI A， et al.Depression and oropharynx cancer outcome［J］. Psychosom Med， 2016， 78（1）: 38-48.
31.LAZURE K E， LYDIATT W M， DENMAN D， et al. Association between depression and survival or disease recurrence in patients with head and neck cancer enrolled in a depression prevention trial［J］. Head Neck， 2009， 31（7）: 888-892.