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Abstract Objective To investigate the effect of probiotics combined with enteral nutrition on intestinal flora and peripheral blood miR-155 in patients with acute pancreatitis. Methods 92 patients with acute pancreatitis admitted to the Department of digestive medicine of our hospital from June 2016 to December 2018 were selected as the study subjects， according to the random number table method， the patients were divided into observation group （n=46） and control group （n=46）， the control group was given enteral nutrition treatment on the basis of routine treatment， while the observation group was given Live Combined Bifidobacterium and Lactobacillus Tablets on the basis of the control group， the changes of intestinal flora， inflammatory mediators and serum miR-155 were observed before and after treatment， and the recovery of gastrointestinal function was compared between the two groups. Results After treatment， the number of bifidobacteria and lactobacillus increased and the number of enterococcus and escherichia coli decreased in observation group， and the reduced serum levels of CRP， IL-6， IL-17， TNF-α， and mi5-155 were significantly higher than those of control group （P<0.05）.The gastrointestinal quality of life scale （GIQLI） score of patients in observation group was higher than that of control group， and the time for the disappearance of abdominal distension， the time for the disappearance of abdominal pain， the time for the recovery of bowel sounds， and the time for the recovery of serum amylase were all less than that of control group （P<0.05）. Conclusion Probiotics combined with enteral nutrition in the treatment of acute pancreatitis can regulate the balance of intestinal flora， reduce the level of serum miR-155， alleviate inflammation and promote the recovery of intestinal function.
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