消化道恶性肿瘤患者FA、VitB<sub>12</sub> 、Fer及HCY的检测与预后分析

doi:10.16689/j.cnki.cn11-9349/r.2020.02.011

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Abstract Objective To investigate the effect of folic acid（FA）， vitamin B12 （VitB12）， ferritin（Fer） and homocysteine（HCY） on the prognosis and survival of gastric cancer， colon cancer and liver cancer patient. Methods From February 2013 to August 2018，a total of 317 patients diagnosed with malignant tumor complicated with anemia were selected from General Hospital of Heilongjiang Province Land Reclamation Bureau， including 113 cases of gastric cancer， 120 cases of colon cancer and 84 cases of liver cancer. Anemia indicators and HCY were detected in 317 patients respectively. Cox regression model was used to analyze the prognostic factors of patients， and Kaplan-Meier method was used to draw the survival curve. Results Multivariate Cox regression analysis showed that VitB12 was an independent prognostic factor in patients with gastric cancer anemia （P=0.008）； The expression level of FA， Fer and HCY can be used as prognostic factors for patients with colon cancer anemia （P=0.01， P=0.001， P=0.002）；Fer and HCY can be used as prognostic factors for patients with liver cancer （P=0.006， P=0.014）. Kaplan-Meier survival curve analysis showed that the level of VitB12 had no significant effect on the survival rate of patients with anemia of stage Ⅰ and Ⅱ gastric cancer （P=0.174）；Patients at stage Ⅲ and Ⅳ， the survival rate of patients lacking VitB12 was significantly lower than that of patients with normal VitB12（P=0.043）. Regardless of stage， the survival rate of colon cancer patients lack FA and HCY increased was poor. In the liver cancer group， survival rates were significantly reduced in patients with Fer and HCY increased，regardless of stage. Conclusion The levels of FA， VitB12， Fer and HCY are significantly correlated with the prognosis of patients with anemia of digestive tract malignant tumors. They can be used as nutritional monitoring indicators for patients with anemia of digestive tract malignant tumors， assisting in determine the anemia degree and type of patients， improving tumor treatment strategy and the prognosis.

Key words： Folic acid Vitamin B12 Ferritin Homocysteine Malignant tumors of the digestive tract

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	Zhou Kun
	Zheng Zunrong
	Zhou Yuzhen

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Zhou Kun,Zheng Zunrong,Zhou Yuzhen. Correlation analysis of FA， VitB₁₂， Fer， HCY and prognosis in patients with malignant tumor of digestive system[J]. Electron J Metab Nutr Cancer, 2020, 7(2): 193-198.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11-9349/r.2020.02.011 OR http://182.92.200.144/EN/Y2020/V7/I2/193

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