1Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei, China；2Shijiazhuang Pharmaceutical Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Limited Liability Company, Shijiazhuang 050031, Hebei, China
Abstract Objective This meta-analysis aimed to evaluate the relationship between pro-inflammatory diet and colorectal cancer (CRC) risk, so as to provide a reference for scientific diet. Methods The PubMed, EM base, Web of Science, Cochrane Library, CNKI, Wanfang Data and VIP Database were retrieved by computer. According to the inclusion criteria, the related studies before July 2019 were collected and evaluated. Dietary inflammation index (DII) was used to evaluate the inflammatory effect of diet. This meta-analysis was carried out by Revman 5.2 software. The odds ratio (OR) value and 95% confidence interval (CI) of the included studies were pooled. At the same time, the subgroup analysis was conducted according to the cancer type and continent. Results A total of ten literatures were included, which enrolled 964 935 cases. Individuals in the highest pro-inflammatory diet category were increased with the incidence of colorectal cancer compared to those in the highest anti-inflammatory diet category (OR=1.43,95％CI=1.28~1.60). Subgroup analysis by cancer type showed that individuals with the highest pro-inflammatory diet category were increased with colon cancer (OR=1.37, 95%CI=1.20~1.57), and rectal cancer (OR=1.33, 95%CI=1.11~1.61). Subgroup analysis by continent showed that：Asia (OR=2.17, 95%CI=1.77~2.68), Europe(OR=1.56, 95%CI=1.32~1.85), North America(OR=1.28, 95％CI=1.21~1.35). Conclusions Dietary patterns with pro-inflammatory diet may increase the risk of colorectal cancer. The correlation between pro-inflammatory diet and colorectal cancer risk in Asia may be higher than that in Europe and North America, but this conclusion needs to be confirmed by further studies.
1Li Xiaoling,1Xie Ying,1Cao Wei, et al. Meta-analysis of pro-inflammatory diet and risk of colorectal cancer[J]. Electron J Metab Nutr Cancer, 2020, 7(1): 104-111.
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