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Abstract Objective To investigate the relationship of uric acid and clinicopathological features and prognosis of patients with advanced colon cancer. Methods The clinical data of 98 patients with stage IV colon cancer were collected and analyzed retrospectively. We analyzed the incidence of hyperuricemia during the natural course of colon cancer patients， and its relationship with the gender， age， degree of differentiation， liver metastasis of these patients. Kaplan-Meier method and multivariate Cox regression model were used to analyze the effect of hyperuricemia on prognosis. Results Among 98 cases of colon cancer patients， 50 (51%) cases were accompanied with hyperuricemia，those median was 488.5(416.3，579.0)μmol/L in male and 453.7(359.7，551.3)μmol/L in female。The incidence of hyperuricemia was marginally related to the gender， age and site (P>0.05) while significantly related to degree of differentiation and liver metastasis (OR=6.315，P<0.01;OR=3.659， P<0.05). The ORR of the patients without hyperuricemia was 70.5%， which is significantly higher than 28% in patients with hyperuricemia (OR=6.245， P<0.01). The median overall survival of the patients with hyperuricemia was 22 months (95%CI=20.915~27.085). It is significantly shorter than 36 months (95%CI=31.688~42.312) of patients without hyperuricemia (HR=4.803，95%CI=2.970~7.769，P<0.01). The results of Cox regression survival analysis showed that the incidence of hyperuricemia was independent factors of prognosis of patients with colon cancer (P<0.05). Conclusion During the natural course of advanced colon cancer， the incidence of hyperuricemia was high. The incidence of hyperuricemia are substantially correlated with degree of differentiation，liver metastasis and ORR. The incidence of hyperuricemia is independent prognosis factors of patients with colon cancer.
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