Investigation of mechanisms of phytochemicals to counteract tumor invasion and metastasis a review
1Zhu Jiayu ，1Cao Peilian ，2Wang Shu'an
1Department of Clinic Nutrition Gangcheng Rehabilitation Hospital of Zhangjiagang Suzhou 215600 Jiangsu China
2Department of
Clinic Nutrition Nanjing Drum Tower Hospital Affiliated Hospital of Nanjing University Medical School Nanjing 210008
Jiangsu China
Abstract：Malignant tumors are caused by the malignant growth of cells which seriously endanger human health and threaten
life. Most deaths from malignant tumors are caused by tumor invasion and metastasis. Through the invasion-metastasis cascade IMC
tumor cells are transferred from the primary focus to distant tissues and successfully colonized. IMC is a complex process involving
multiple factors and steps. Multiple signal pathways can promote tumor invasion and metastasis. Phytochemicals have been proved to
block tumor invasion and metastasis by inhibiting the formation of these signal pathways. Epithelial mesenchymal transformation EMT
in the IMC process will strengthen tumor drug resistance and radiation resistance. Because of the mutual promotion between tumor
invasion and metastasis with drug and radiation resistance and the shortcomings of large side effects and poor effects of anti-tumor
therapy it is urgent to find safe and effective drugs with anti - tumor invasion and metastasis and radiochemotherapy sensitization
effect. Studies have shown that phytochemicals have a variety of biological activities. If they are used alone or in combination with
anti-tumor therapy they can inhibit tumor invasion and metastasis reduce the toxicity of anti - tumor therapy and improve the
radiochemotherapy sensitivity. The purpose of this article is to review the current status and developments of phytochemicals as an anti
signal pathway in inhibiting IMC antitumor invasion and anti-metastasis therapy in recent years in order to provide ideas for future
research on anti-tumor invasion and metastasis of phytochemicals.
