1Department of Oncology Fourth Affiliated Hospital of Guangxi Medical University Liuzhou 545005 Guangxi China
2Department of Oncology Liuzhou Traditional Chinese Medical Hospital Liuzhou 545001 Guangxi China
3Department of Comprehensive Oncology National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital Chinese Academy of Medical Sciences and Peking Union
Medical College Beijing 100021 China
Abstract：The safety of soybean consumption in patients with breast cancer is still controversial. On the one hand it is believed
that soybean isoflavones may stimulate the generation of reactive oxygen species and play a certain role in the initiation of breast cancer
and the proliferation of cancer cells. On the other hand other studies have shown that after ingesting foods containing soybeans the
isoflavone concentration in the serum increased significantly but the isoflavone concentration in the breast tissue changes little. At the
same time consumption of isoflavone had no effect on Ki-67 a molecular marker of proliferative activity in breast tissue and the density of mammograms. Isoflavone intake has no adverse effect on the incidence of breast cancer in premenopausal and postmenopausal
women but has the effect of preventing breast cancer. At the same time the intake of isoflavones had no effect on the proliferation of
breast tissue. For breast cancer survivors after treatment intake of soybean and isoflavones had no significant adverse effects on prognosis and even had a protective effect on postmenopausal breast cancer patients. Therefore according to the epidemiological and clinical
evidence obtained at present combined with the 2016 edition of Chinese Dietary Guidelines it is suggested that 10~ 25 g of soybeans
or a considerable amount of soybean products should be taken per person per day and women diagnosed with breast cancer should eat
soybeans appropriately. This article reviews the role of soybean isoflavones in the prevention of breast cancer whether it has an impact
on proliferation whether it will affect breast cancer patients and the mechanism of soybean isoflavones on the pathogenesis and prognosis of breast cancer
收稿日期: 2022-02-22
基金资助:吴阶平医学基金会临床科研专项资助基金
(320. 6750. 2021-06-9)
通讯作者:
丛明华,电子邮箱:congmh@cicams.ac.cn
引用本文:
1张日光,2阳 柳,1陈海辉,1陈绍俊,3丛明华. 大豆异黄酮对乳腺癌发病和预后的影响及研究进展[J]. 肿瘤代谢与营养电子杂志, 2022, 9(3): 401-407.
1Zhang Riguang，2Yang Liu，1Chen Shaojun，1Chen Haihui，3Cong Minghua. Effect and research progress of soybean isoflavones on incidence and prognosis of breast cancer. Electron J Metab Nutr Cancer, 2022, 9(3): 401-407.
