Clinical operation and application of fecal microbiota transplantation
1Wang Yuying，1 2Shi Hanping，1 2Rao Benqiang
1Department of Gastrointestinal Surgery / Clinical Nutrition Beijing Shijitan Hospital Capital Medical University Beijing 100038 China
2Key Laboratory of Cancer FSMP for State Market Regulation Beijing 100038 China
Abstract：Fecal microbiota transplantation FMT has been successfully used to treat recurrent C. difficile infections as an effective regimen to improve dysbiosis. With the deepening of scientific research on intestinal flora FMT technology has also been gradually
applied to clinical treatment of various diseases and has become a new treatment solution for improving digestive endocrine nervous
and other systemic diseases. However there is no unified standard for the clinical operation and application of FMT. From the collection of fecal bacteria donors to the transplantation of flora and then to the monitoring of postoperative efficacy the selection of donors
preparation of fecal bacteria storage conditions selection of transplantation techniques and postoperative supervision and management
in various countries and regions all have different views or standards. This article refers to clinical and scientific research cases in
many countries and regions in Europe and Asia combined with clinical experience and analyzes the procedures from donor screening
collection and storage of fecal bacteria samples and selection of transplant surgery. The various schemes of FMT in current clinical application are comprehensively introduced and the advantages and disadvantages between different clinical operating standards are discussed. In addition we introduced and evaluated the indications and contraindications for the clinical application of FMT the occurrence of postoperative adverse events and the monitoring of postoperative efficacy in order to reduce unnecessary damage to patients'
health by standardizing the scope of clinical applications. Finally the whole process of FMT clinical operation is summarized and corresponding clinical application suggestions are given. We expect to provide clinicians with a reference for FMT surgical specifications.
We expect to provide clinicians with reference to FMT operating standards.
收稿日期: 2022-03-21
基金资助:北京市自然科学基金(7202076)
通讯作者:
饶本强,电子邮箱:raobenqiang@bjsjth.cn
引用本文:
1王玉莹,1,2石汉平,1,2饶本强. 粪菌移植的临床操作与应用[J]. 肿瘤代谢与营养电子杂志, 2022, 9(3): 390-395.
1Wang Yuying，1 2Shi Hanping，1 2Rao Benqiang. Clinical operation and application of fecal microbiota transplantation. Electron J Metab Nutr Cancer, 2022, 9(3): 390-395.
