Study on risk factors and comprehensive measures of radiation enteritis after concurrent radiotherapy and chemotherapy for
cervical squamous cell carcinoma
Zhou Chao, Zhu Ying, Xu Dejing, Huan Jianying
Radiation Department, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital,
Nanjing 210009, Jiangsu, China
Abstract：Objective To explore the risk factors and therapeutic effects of concurrent radiotherapy and chemotherapy in patients
with cervical squamous cell carcinoma. Method A total of 500 patients with cervical squamous cell carcinoma treated and treated with
radical resection in Nanjing Medical University Cancer Hospital from January 2019 to March 2021 were selected. According to the
occurrence of radiation enteritis during the same period of radiotherapy and chemotherapy, they were divided into radiation enteritis group
and control group. Multivariable Logistic regression analysis were used to determine the influence factors of concurrent chemoradiation
radioactive enteritis of the cervical squamous carcinoma patients during the same period. The patients in the radiation enteritis group were
given personalized bladder filling training, traditional Chinese medicine retention enema nursing, rational radiotherapy program,
psychological nursing and health education and other nursing interventions. To calculate the nursing clinical efficacy of patients with
radiation enteritis, and to compare the proportion of patients with radiation enteritis symptom severity≥2 grade before and after nursing
intervention. Result 225 cases had radiation enteritis, and the incidence rate was 45%. Multivariate Logistic regression analysis showed
that≥60 years old (OR=7.253, 95%CI=3.294-15.970), stage Ⅲ tumor (OR=38.705, 95%CI=12.546-119.410), tumor diameter≥4 cm
(OR=11.669, 95%CI=4.868-27.970), average radiation dose≥60 Gy (OR=40.223, 95%CI=14.460-111.883) were risk factors for the
occurrence of radiation enteritis during concurrent radiotherapy and chemotherapy, and good nutrition (OR=2.474, 95%CI=1.108-5.527)
was a protective factor for the occurrence of radiation enteritis. The therapeutic effect of radiation enteritis in 225 patients was 94.67%.
Compared with before intervention, the proportion of symptom severity≥2 grade in 225 patients with radiation enteritis significantly
decreased after intervention, 69.33% and 32.00% (P<0.05). Conclusion Age≥60 years, tumor stage Ⅲ, tumor diameter≥4 cm, average
radiation dose≥60 Gy are the risk factors for the occurrence of radiation enteritis in patients with cervical squamous cell carcinoma during
concurrent radiotherapy and chemotherapy. Good nutrition is a protective factor, and the patients with the above risk factors should be
targeted for prevention and intervention.
