Application of nutritional management during postoperative chemotherapy in children with high‑risk neuroblastoma
1Zhao Wenli, 2Ma Xiaoli, 1Yang Wenli, 1Xia Lulu, 1Yan Jie
1Department of Clinical Nutrition, Beijing Children’s Hospital, Capital Medical UniVersity, National Center for Children’s Health, Beijing
100045, China; 2Beijing Key Laboratory of Pediatric Hematology Oncology, National Discipline of Pediatrics, Ministry of Education, MOE
Key Laboratory of Major Diseases in Children, Hematology Oncology Center, Beijing Children’s Hospital, Capital Medical University, National
Center for Children's Health, Beijing 100045, China
Abstract：Objective To investigate the effect of nutritional management during postoperative chemotherapy in children with
neuroblastoma. Method A total of 88 neuroblastoma patients treated in Hematology Oncology Center, Beijing Children’s Hospital, Capital
Medical University from November 2019 to March 2021 after chemotherapy were randomly divided into control group and observation
group, 44 patients each. The control group received routine diet nursing, and the observation group received whole⁃course nutrition
management on the basis of routine nursing. Centralized management in the hospital and Wechat group management established outside
the hospital lasted for 3 months. Nutritional indicators and adverse reactions of patients in the two groups during postoperative
chemotherapy were compared. Result The absolute values of serum prealbumin [ (169.66±30.46) mg/L vs (158.68±19.18) mg/L], serum
albumin [(44.86±3.72) mg/L vs (42.90±4.47) mg/L], hemoglobin [(108.23±14.16) g/L vs (102.36±11.37) mg/L] and lymphocytes [0.91
(0.64, 1.11)×109 vs 0.68 (0.42, 1.02)×109] in the observation group were higher than those in the control group (P<0.05); the weight gain
was higher than that of the control group, but there was no significant difference (P=0.238). The incidence of adverse reactions, such as
malnutrition risk screening score [(5.23±1.51）vs（6.05±1.90）], infection [10 (22.7%) vs 19 (43.2%)], anorexia [15 (34.1%) vs 29 (65.9%)]
and reduced chemotherapy intensity [1 (2.3%) vs 6 (13.6%)] were lower in the observation group than in the control group. The difference
was statistically significant (P<0.05). The incidence of malnutrition and diarrhea was lower than that of control group (P>0.05). Conclusion
Nutritional management can effectively improve the nutritional status of patients after tumor operation and reduce the incidence of
malnutrition and adverse reactions of chemotherapy.
