维生素B6与肺癌关系研究进展

doi:10.16689/j.cnki.cn11-9349/r.2020.01.020

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摘要目前肺癌是对人类生命健康威胁重大的恶性肿瘤，发病率高、病死率高。全程管理和包括营养治疗的综合治疗尤为重要。维生素B6作为重要B族维生素，广泛参与机体合成与代谢反应。但是，维生素B6在不同疾病的发生、发展和治疗中的作用尚未完全清晰。本文综合国内外进展初步探讨维生素B6对肺癌的发生风险与疾病进展的影响，了解维生素B6的需求情况是否会在肺癌疾病发生、进展和治疗不同的阶段而发生变化。结合这些研究，本文得出以下几点提示：血清维生素B6水平与肺癌发生风险呈负相关，但对于健康人群或者非肺癌人群，膳食补充维生素B6不能减低肺癌发生风险，高剂量补充维生素B6可能有害。机体维生素B6明显缺乏时，罹患肺癌的风险增加。对于肿瘤人群，维生素B6单独或联合其他营养素使用可抑制肿瘤细胞增殖和迁移，诱导抗肿瘤细胞因子产生，发挥抗肿瘤作用。因此维生素B6的摄入和补充应首先进行机体健康状况尤其是机体维生素B6水平的评估。

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	刘彩萍
	魏蕾
	刘燕青

关键词 ：维生素B6, 肺癌, 磷酸吡哆醛, 吡哆醛激酶, 顺铂

Abstract：At present, lung cancer is a malignant cancer with high incidence and mortality rate which threatens human health. System management and comprehensive treatment including nutritional treatment are particularly important. Vitamin B6, as one of the most important B vitamins, is widely involved in body synthesis and metabolic reactions. However, the role of vitamin B6 in the occurrence, development, and treatment of different diseases is not fully understood. In this study, the effects of vitamin B6 on the risk and progression of lung cancer were discussed, and whether the demand of vitamin B6 would change in different stages of the occurrence, progression and treatment of lung cancer was understood. Combining these studies, we draws the following points： 1. The level of serum vitamin B6 was negatively correlated with the risk of lung cancer. However, for healthy or non-lung cancer people, dietary or vitamin B6 supplement could not reduce the risk of lung cancer, and high dose vitamin B6 supplementation might be harmful. 2. When the body is significantly deficient in vitamin B6, the risk of lung cancer increases. 3. For cancer patients, vitamin B6 alone or in combination with other nutrients can inhibit the proliferation and migration of cancer cells, induce the production of anti-tumor cytokines, and play an anti-tumor role. Therefore, the intake and supplement of vitamin B6 should first evaluate the health status of the body, especially the level of vitamin B6.

Key words： Vitamin B6 Lung cancer Pyridoxal phosphate Pyridoxal kinase Cisplatin

通讯作者: 刘彩萍，电子邮箱：lcpnutrition@163.com

引用本文:

刘彩萍，魏蕾，刘燕青. 维生素B6与肺癌关系研究进展[J]. 肿瘤代谢与营养电子杂志, 2020, 7(1): 112-116.
Liu Caiping, Wei Lei, Liu Yanqing. Research progress on the relationship between vitamin B6 and lung cancer. Electron J Metab Nutr Cancer, 2020, 7(1): 112-116.

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